2016
DOI: 10.3892/ol.2016.4468
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Downregulating microRNA-144 mediates a metabolic shift in lung cancer cells by regulating GLUT1 expression

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Cited by 50 publications
(39 citation statements)
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“…In lung cancer, miR-144 was verified to be significantly downregulated. 20 Chen et al 21 corroborated that miR-144 inhibited propagation and induced apoptosis and autophagy in lung cancer cells by targeting TIGAR. To examine the role of miR-144-3p in LUAD cells, we firstly detect the expression level of miR-144-3p in LUAD.…”
Section: Discussionmentioning
confidence: 93%
See 1 more Smart Citation
“…In lung cancer, miR-144 was verified to be significantly downregulated. 20 Chen et al 21 corroborated that miR-144 inhibited propagation and induced apoptosis and autophagy in lung cancer cells by targeting TIGAR. To examine the role of miR-144-3p in LUAD cells, we firstly detect the expression level of miR-144-3p in LUAD.…”
Section: Discussionmentioning
confidence: 93%
“…It has been reported in previous studies that miR‐144‐3p has complicated regulation mechanism in different types of tumors. In lung cancer, miR‐144 was verified to be significantly downregulated . Chen et al corroborated that miR‐144 inhibited propagation and induced apoptosis and autophagy in lung cancer cells by targeting TIGAR.…”
Section: Discussionmentioning
confidence: 93%
“…Chen et al[87] demonstrated that miR-22 regulates GLUT1 expression and inhibits the proliferation and invasion of breast cancer. MicroRNA-144 was also reported to mediate the metabolic shift by regulating GLUT1 expression in lung and ovarian cancers[88,89]. Moreover, miR-195-5p inhibits the glucose uptake by down-regulating GLUT3 expression and thus reduces proliferation in bladder cancer cells[90].…”
Section: Regulatory Mechanism Of Glucose Metabolic Reprogrammingmentioning
confidence: 99%
“…Studies have found that most malignant tumors increase the efficiency of glucose uptake by upregulating the expression of GLUT. GLUT1 is highly expressed in non‐small cell lung cancer and is associated with [ 18 F]‐FDG uptake . Upon entry, glucose is converted to 6‐glucose phosphate under HK, which is the first stage of glycolysis.…”
Section: Discussionmentioning
confidence: 99%
“…GLUT1 is highly expressed in non-small cell lung cancer and is associated with [ 18 F]-FDG uptake. 21,22 Upon entry, glucose is converted to 6-glucose phosphate under HK, which is the first stage of glycolysis. HK plays a dominant role in glycolysis by promoting the coupling of ATP with glucose phosphorylation.…”
Section: Du Et Almentioning
confidence: 99%