2013
DOI: 10.1016/j.bbamcr.2013.07.021
|View full text |Cite
|
Sign up to set email alerts
|

Downregulation of CFTR promotes epithelial-to-mesenchymal transition and is associated with poor prognosis of breast cancer

Abstract: The epithelial-to-mesenchymal transition (EMT), a process involving the breakdown of cell-cell junctions and loss of epithelial polarity, is closely related to cancer development and metastatic progression. While the cystic fibrosis transmembrane conductance regulator (CFTR), a Cl(-) and HCO3(-) conducting anion channel expressed in a wide variety of epithelial cells, has been implicated in the regulation of epithelial polarity, the exact role of CFTR in the pathogenesis of cancer and its possible involvement … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

7
106
0

Year Published

2014
2014
2020
2020

Publication Types

Select...
7
1

Relationship

2
6

Authors

Journals

citations
Cited by 105 publications
(113 citation statements)
references
References 45 publications
7
106
0
Order By: Relevance
“…A functional role for CFTR in EMT induction is suggested by the ability of CFTR silencing to induce the expression of a variety of mesenchymal markers in MCF-7 breast cancer cells. This proposed function of CFTR is further supported by the ability of CFTR overexpression in mesenchymal-like MDA-MB-231 breast cancer cells to suppress the expression of vimentin (a mesenchymal marker) and induce the expression of E-cadherin (an epithelial marker) (Zhang et al 2013a). As would be predicted based on these results, reduced levels of CFTR are associated with poor prognosis in breast cancer patients (Zhang et al 2013a).…”
Section: Chloride Channels and Emt In Cancer Cellssupporting
confidence: 53%
See 2 more Smart Citations
“…A functional role for CFTR in EMT induction is suggested by the ability of CFTR silencing to induce the expression of a variety of mesenchymal markers in MCF-7 breast cancer cells. This proposed function of CFTR is further supported by the ability of CFTR overexpression in mesenchymal-like MDA-MB-231 breast cancer cells to suppress the expression of vimentin (a mesenchymal marker) and induce the expression of E-cadherin (an epithelial marker) (Zhang et al 2013a). As would be predicted based on these results, reduced levels of CFTR are associated with poor prognosis in breast cancer patients (Zhang et al 2013a).…”
Section: Chloride Channels and Emt In Cancer Cellssupporting
confidence: 53%
“…This proposed function of CFTR is further supported by the ability of CFTR overexpression in mesenchymal-like MDA-MB-231 breast cancer cells to suppress the expression of vimentin (a mesenchymal marker) and induce the expression of E-cadherin (an epithelial marker) (Zhang et al 2013a). As would be predicted based on these results, reduced levels of CFTR are associated with poor prognosis in breast cancer patients (Zhang et al 2013a). More recent studies have begun to explore chloride channels in the context of EMT in other cancer types, such as squamous cell carcinomas of the head and neck (Shiwarski et al 2014).…”
Section: Chloride Channels and Emt In Cancer Cellsmentioning
confidence: 79%
See 1 more Smart Citation
“…A recent study also demonstrated an important role of CFTR in regulating epithelial-mesenchymal transition (EMT) in breast cancer. 100 Interestingly, CFTR has been shown to be downregulated by TGF-b 101 and miR-155 implicated in the TGFb-induced EMT process and cancer metastasis. 102 Therefore, it may be possible that CFTR mediates the effect of TGF-b on EMT and cancer metastasis through its action on miR-155 and thus the downstream EMT-associated target genes in breast cancer.…”
Section: Micrornas and Cftrmentioning
confidence: 99%
“…CFTR may be a tumor suppressor or promoter, according to the type of tumor. [35][36][37][38][39][40] At present, the relationship between CFTR and autophagy in tumor cells remains unclear. So we next investigated whether CFTR regulates conventional autophagy in tumor cells.…”
Section: Cftr Positively Regulates Cell Autophagy In Tumor Cellsmentioning
confidence: 99%