Downregulation of Collagen<i>COL4A6</i>Is Associated with Prostate Cancer Progression and Metastasis

Ma, Jianbin; Bai, Ji-Yu; Gu, Lijiang; He, Dalin; Guo, Peng

doi:10.1089/gtmb.2020.0009

Cited by 24 publications

(16 citation statements)

References 18 publications

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“…COL4A6 and GADL1 are related to cancer. The downregulation of COL4A6 was associated with prostate cancer progression and metastasis, and the overexpression of GADL1 was associated with cancer cell migration and morphology (including cell area, thickness, volume, perimeter length, irregularity, and eccentricity) [46,47]. The expression of COL4A6 and GADL1 may be regulated by alternative splicing-coupled NMD to promote the development of cancer.…”

Section: Discussionmentioning

confidence: 99%

TF–RBP–AS Triplet Analysis Reveals the Mechanisms of Aberrant Alternative Splicing Events in Kidney Cancer: Implications for Their Possible Clinical Use as Prognostic and Therapeutic Biomarkers

2021

IJMS

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Aberrant alternative splicing (AS) is increasingly linked to cancer; however, how AS contributes to cancer development still remains largely unknown. AS events (ASEs) are largely regulated by RNA-binding proteins (RBPs) whose ability can be modulated by a variety of genetic and epigenetic mechanisms. In this study, we used a computational framework to investigate the roles of transcription factors (TFs) on regulating RBP-AS interactions. A total of 6519 TF–RBP–AS triplets were identified, including 290 TFs, 175 RBPs, and 16 ASEs from TCGA–KIRC RNA sequencing data. TF function categories were defined according to correlation changes between RBP expression and their targeted ASEs. The results suggested that most TFs affected multiple targets, and six different classes of TF-mediated transcriptional dysregulations were identified. Then, regulatory networks were constructed for TF–RBP–AS triplets. Further pathway-enrichment analysis showed that these TFs and RBPs involved in triplets were enriched in a variety of pathways that were associated with cancer development and progression. Survival analysis showed that some triplets were highly associated with survival rates. These findings demonstrated that the integration of TFs into alternative splicing regulatory networks can help us in understanding the roles of alternative splicing in cancer.

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Section: Discussionmentioning

confidence: 99%

TF–RBP–AS Triplet Analysis Reveals the Mechanisms of Aberrant Alternative Splicing Events in Kidney Cancer: Implications for Their Possible Clinical Use as Prognostic and Therapeutic Biomarkers

2021

IJMS

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“…Aberrant DNA methylation is an epigenetic hallmark of cancer and is known to play an important role in tumorigenesis and progression. Meanwhile, with the advancement of bioinformatics technology, it is feasible to identify novel methylation biomarkers via integrative multi-web tools [ 31 – 33 ]. Definitely, before these markers can be used clinically to benefit patients, a series of worldwide clinical evaluation studies are needed.…”

Section: Discussionmentioning

confidence: 99%

SOX14 hypermethylation as a tumour biomarker in cervical cancer

et al. 2021

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Background The association between SOX14 and cancer has been reported. The aim of this study was to identify and validate the potential value of SOX14 methylation in the early detection of cervical cancer. Methods First, we extracted the data for SOX14 methylation and expression within cervical cancer from The Cancer Genome Atlas (TCGA) database and analysed them via UALCAN, Wanderer, MEXPRESS and LinkedOmics. Subsequently, according to the bioinformatics findings, primers and probes were designed for the most significantly differentiated methylation CpG site and synthesized for methylation-specific PCR (MSP) and quantitative methylation-specific PCR (QMSP) to verify SOX14 methylation in both cervical tissuses and liquid-based cell samples. Eventually, the clinical diagnostic efficacy of SOX14 methylation in the normal, cervical intraepithelial neoplasia, and cancer groups was analysed by ROCAUC. Results Pooled analysis demonstrated that SOX14 methylation levels were significantly increased in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) compared to normal tissues (P < 0.001). Both the verification and validation cohorts indicated that the methylation level and the positive rate of SOX14 gradually increased with increasing severity from normal to cancer samples (P < 0.01). When the cut-off value was set as 128.45, the sensitivity and specificity of SOX14 hypermethylation in the diagnosis of cervical cancer were 94.12 and 86.46%, respectively. When taken as a screening biomarker (>CINII), the sensitivity was 74.42% and the specificity was 81.48%, with a cut-off value of 10.37. Conclusion SOX14 hypermethylation is associated with cervical cancer and has the potential to be a molecular biomarker for the screening and early diagnosis of cervical cancer.

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“…The downregulation of COL4A6 may promote the progression and invasion of PRAD by activating the p‐FAK/MMP‐9 signaling pathway. 34 FLRT2 is a typical member of the FLRT family, and encodes cell adhesion molecules. The diverse methylation of the FLRT2 transcription start site could contribute to modulating the expression and the interaction of FLRT2 and FGFR2 , thereby regulating PRAD progression.…”

Section: Discussionmentioning

confidence: 99%

Novel immune‐related signature for risk stratification and prognosis in prostatic adenocarcinoma

et al. 2021

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Downregulation of CollagenCOL4A6Is Associated with Prostate Cancer Progression and Metastasis

Cited by 24 publications

References 18 publications

TF–RBP–AS Triplet Analysis Reveals the Mechanisms of Aberrant Alternative Splicing Events in Kidney Cancer: Implications for Their Possible Clinical Use as Prognostic and Therapeutic Biomarkers

TF–RBP–AS Triplet Analysis Reveals the Mechanisms of Aberrant Alternative Splicing Events in Kidney Cancer: Implications for Their Possible Clinical Use as Prognostic and Therapeutic Biomarkers

SOX14 hypermethylation as a tumour biomarker in cervical cancer

Novel immune‐related signature for risk stratification and prognosis in prostatic adenocarcinoma

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