Downregulation of hepatic β-adrenergic receptors after trauma and hemorrhagic shock

Tait, SM; Wang, P; Zf, Ba; Ih, Chaudry

doi:10.1016/0300-9572(96)84929-x

Cited by 1 publication

(1 citation statement)

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“…(108) In a hemorrhagic shock model, mice were pretreated with either propranolol or metoprolol, and both agents significantly reduced the number of circulating natural killer cells and CD8 + lymphocytes. (105) These effects may be due in part to catecholamine-induced changes in adhesion molecule and chemoattractant receptor expression.…”

Section: Immunomodulation After Traumamentioning

confidence: 99%

β-Blockade use for Traumatic Injuries and Immunomodulation

Loftus

Efron

Moldawer

et al. 2016

Shock

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Sympathetic nervous system activation and catecholamine release are important events following injury and infection. The nature and timing of different pathophysiologic insults have significant effects on adrenergic pathways, inflammatory mediators, and the host response. Beta adrenergic receptor blockers (β-blockers) are commonly used for treatment of cardiovascular disease but recent data suggests that the metabolic and immunomodulatory effects of β-blockers can expand their use. β-blocker therapy can reduce sympathetic activation and hypermetabolism as well as modify glucose homeostasis and cytokine expression. It is the purpose of this review to examine either the biologic basis for proposed mechanisms or to describe current available clinical evidence for the use of β-blockers in traumatic brain injury (TBI), spinal cord injury (SCI), hemorrhagic shock, acute traumatic coagulopathy, erythropoietic dysfunction, metabolic dysfunction, pulmonary dysfunction, burns, immunomodulation, and sepsis.

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Section: Immunomodulation After Traumamentioning

confidence: 99%