Downregulation of HLA Class I Molecules in Primary Oral Squamous Cell Carcinomas and Cell Lines

Tang, Qiusha; Zhang, Jianqiong; Qi, Bing; Shen, Chuanlai; Xie, Wei

doi:10.1016/j.arcmed.2009.04.004

Cited by 14 publications

(11 citation statements)

References 29 publications

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“…The data obtained for HPV‐negative TSCC were expected and in line with many other studies on different tumors including several HNSCC subsites, oral SCC or laryngeal SCC, demonstrating a positive correlation between high HLA class I expression and good prognosis, but none of these have taken HPV status into account 15, 18, 19, 38. However, the difference in frequency of HPV‐negative TSCC with low HLA expression between the groups with good and poor clinical outcome (9% vs .…”

Section: Discussionsupporting

confidence: 84%

MHC class I expression in HPV positive and negative tonsillar squamous cell carcinoma in correlation to clinical outcome

Näsman

Andersson

Nordfors

et al. 2012

Intl Journal of Cancer

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Human papillomavirus (HPV) is an important factor for the development of tonsillar squamous cell carcinoma (TSCC). In addition, patients with HPV‐positive TSCC have a better clinical outcome than patients with HPV‐negative TSCC. Although, HPV is an important prognostic marker, additional biomarkers are needed to better predict clinical outcome to individualize treatment. Hence, we examined if classical HLA HLA‐A,B,C and nonclassical HLA‐E,G could serve as such marker. Formalin‐fixed paraffin‐embedded TSCC from 150 patients diagnosed 2000–2006, earlier analyzed for HPV DNA and p16INK4a, and treated with intention to cure were evaluated for the expression of HLA‐A,B,C and HLA‐E,G by immunohistochemistry. For HPV‐positive TSCC a low expression of HLA‐A,B,C, whereas for HPV‐negative TSCC, a normal expression of HLA‐A,B,C was significantly correlated to a favorable clinical outcome. These correlations were more pronounced for membrane staining of HLA‐A,B,C when compared with cytoplasmatic staining. No significant correlation was found between HLA‐E,G and HPV status or clinical outcome. The unexpected contrasting correlation between HLA‐A,B,C expression, and clinical outcome depending on HPV, indicates essential differences between HPV‐positive and HPV‐negative TSCC. Furthermore, our data demonstrate that for both HPV‐positive and HPV‐negative TSCC, the expression of HLA‐A,B,C together with HPV may serve as a useful biomarker for predicting clinical outcome.

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Section: Discussionsupporting

confidence: 84%

MHC class I expression in HPV positive and negative tonsillar squamous cell carcinoma in correlation to clinical outcome

Näsman

Andersson

Nordfors

et al. 2012

Intl Journal of Cancer

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“…[34] Previous studies have found that HLA class I antigen processing machinery associated with antigen processing plays an important role in head and neck SCC, [35] and HLA class I molecules are downregulated in OSCC. [36] The overexpression of MHC class I chain-related protein A in OSCC is related to enhanced cytotoxicity to target tumor cells. [37] …”

Section: Discussionmentioning

confidence: 99%

A genome-wide association scan of biological processes involved in oral lichen planus and oral squamous cell carcinoma

Yang

Sun

et al. 2017

Medicine

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“…Their frequency ranges from 0–90%. Depending on tumor types, these defects have been associated with aggressive histopathological features as well as poor survival [ 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 ]. Most of the defects are caused by genetic or epigenetic mutations as well as by transcriptional or post-translational modifications [ 145 , 148 , 149 ].…”

Section: Defects and Clinical Significance Of Hla In Human Cancermentioning

confidence: 99%

Role of Human Leukocyte Antigen System as A Predictive Biomarker for Checkpoint-Based Immunotherapy in Cancer Patients

Sabbatino

Liguori

Polcaro

et al. 2020

IJMS

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Recent advances in cancer immunotherapy have clearly shown that checkpoint-based immunotherapy is effective in a small subgroup of cancer patients. However, no effective predictive biomarker has been identified so far. The major histocompatibility complex, better known in humans as human leukocyte antigen (HLA), is a very polymorphic gene complex consisting of more than 200 genes. It has a crucial role in activating an appropriate host immune response against pathogens and tumor cells by discriminating self and non-self peptides. Several lines of evidence have shown that down-regulation of expression of HLA class I antigen derived peptide complexes by cancer cells is a mechanism of tumor immune escape and is often associated to poor prognosis in cancer patients. In addition, it has also been shown that HLA class I and II antigen expression, as well as defects in the antigen processing machinery complex, may predict tumor responses in cancer immunotherapy. Nevertheless, the role of HLA in predicting tumor responses to checkpoint-based immunotherapy is still debated. In this review, firstly, we will describe the structure and function of the HLA system. Secondly, we will summarize the HLA defects and their clinical significance in cancer patients. Thirdly, we will review the potential role of the HLA as a predictive biomarker for checkpoint-based immunotherapy in cancer patients. Lastly, we will discuss the potential strategies that may restore HLA function to implement novel therapeutic strategies in cancer patients.

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Downregulation of HLA Class I Molecules in Primary Oral Squamous Cell Carcinomas and Cell Lines

Cited by 14 publications

References 29 publications

MHC class I expression in HPV positive and negative tonsillar squamous cell carcinoma in correlation to clinical outcome

MHC class I expression in HPV positive and negative tonsillar squamous cell carcinoma in correlation to clinical outcome

A genome-wide association scan of biological processes involved in oral lichen planus and oral squamous cell carcinoma

Role of Human Leukocyte Antigen System as A Predictive Biomarker for Checkpoint-Based Immunotherapy in Cancer Patients

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