Downregulation of lncRNA-ATB correlates with clinical progression and unfavorable prognosis in pancreatic cancer

Qu, Shibin; Yang, Xisheng; Song, Wenjie; Sun, Wei; Li, Xiaolei; Wang, Jianlin; Zhong, Yue; Shang, Runze; Ruan, Bai; Zhang, Zhuochao; Zhang, Xuan; Li, Haimin

doi:10.1007/s13277-015-4252-y

Cited by 54 publications

(45 citation statements)

References 27 publications

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“…This was validated in our current study, in which elevated lnc-ATB expression was positively correlated with ESCC carcinogenesis. However, Qu et al 18 reported that expression of lnc-ATB decreased in pancreatic cancer tissues and cell lines, and decreased lnc-ATB expression was an independent predictor of poor prognosis in pancreatic cancer patients. Overall, these data suggest that there is a cancer specific expression pattern of lnc-ATB.…”

Section: Discussionmentioning

confidence: 99%

“…12 Moreover, lnc-ATB could promote trastuzumab resistance and the invasion-metastasis cascade in breast cancer by competitively binding miR-200c and upregulating ZEB1 and ZNF-217, resulting in EMT. 13 Dysregulation of lnc-ATB have been reported in human tumors including gastric, 14 colorectal, 15, 16 brain, 17 pancreatic 18 and renal 19 cancer. However, expression of lnc-ATB in ESCC and the underlying mechanisms remain unsolved.…”

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confidence: 99%

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Long non-coding RNA ATB promotes malignancy of esophageal squamous cell carcinoma by regulating miR-200b/Kindlin-2 axis

et al. 2017

Cell Death Dis

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Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer-related death, especially in China. In addition, the prognosis of late stage patients is extremely poor. However, the biological significance of the long non-coding RNA lnc-ATB and its potential role in ESCC remain to be documented. In this study, we investigated the role of lnc-ATB and the underlying mechanism promoting its oncogenic activity in ESCC. Expression of lnc-ATB was higher in ESCC tissues and cell lines than that in normal counterparts. Upregulated lnc-ATB served as an independent prognosis predictor of ESCC patients. Moreover, loss-of-function assays in ESCC cells showed that knockdown of lnc-ATB inhibited cell proliferation and migration both in vitro and in vivo. Mechanistic investigation indicated that lnc-ATB exerted oncogenic activities via regulating Kindlin-2, as the anti-migration role of lnc-ATB silence was attenuated by ectopic expression of Kindlin-2. Further analysis showed that lnc-ATB functions as a molecular sponge for miR-200b and Kindlin-2. Dysregulated miR-200b/Kindlin-2 signaling mediated the oncogenic activity of lnc-ATB in ESCC. Our results suggest that lnc-ATB predicts poor prognosis and may serve as a potential therapeutic target for ESCC patients.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Long non-coding RNA ATB promotes malignancy of esophageal squamous cell carcinoma by regulating miR-200b/Kindlin-2 axis

et al. 2017

Cell Death Dis

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“…However, in contrast to the above findings in other malignancies, lncRNA-ATB was found to be downregulated in pancreatic cancer, with low levels being associated with advanced and metastatic disease [293]. Likewise, miR-200a and miR-200b, have been shown to be overexpressed in pancreatic cancer despite being downregulated in many other cancers [294].…”

Section: Lncrnas and Emt: The Main Playersmentioning

confidence: 99%

Long Non-Coding RNAs: Key Regulators of Epithelial-Mesenchymal Transition, Tumour Drug Resistance and Cancer Stem Cells

Heery

Finn

Cuffe

et al. 2017

Cancers

163

140

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Epithelial mesenchymal transition (EMT), the adoption by epithelial cells of a mesenchymal-like phenotype, is a process co-opted by carcinoma cells in order to initiate invasion and metastasis. In addition, it is becoming clear that is instrumental to both the development of drug resistance by tumour cells and in the generation and maintenance of cancer stem cells. EMT is thus a pivotal process during tumour progression and poses a major barrier to the successful treatment of cancer. Non-coding RNAs (ncRNA) often utilize epigenetic programs to regulate both gene expression and chromatin structure. One type of ncRNA, called long non-coding RNAs (lncRNAs), has become increasingly recognized as being both highly dysregulated in cancer and to play a variety of different roles in tumourigenesis. Indeed, over the last few years, lncRNAs have rapidly emerged as key regulators of EMT in cancer. In this review, we discuss the lncRNAs that have been associated with the EMT process in cancer and the variety of molecular mechanisms and signalling pathways through which they regulate EMT, and finally discuss how these EMT-regulating lncRNAs impact on both anti-cancer drug resistance and the cancer stem cell phenotype.

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“…Qu et al reported that lncRNA-ATB was directly correlated with clinical endpoints (overall survival) and could serve as an independent prognosis maker for pancreatic cancer patients [15]. Saito et al showed that increased lncRNA-ATB expression was a significant prognostic for increased recurrence and decreased survival of GC patients [26].…”

Section: Discussionmentioning

confidence: 99%

“…For example, a high expression of lncRNA-ATB participated in the development of colorectal cancer (CRC) and was a novel indicator of poor prognosis in patients with CRC [14]. Low expression of lncRNA-ATB plays a critical role in pancreatic cancer progression and prognosis, and may serve as a potential prognostic biomarker in pancreatic cancer patients [15]. However, the study investigated the role of lncRNAs in CWP is limited.…”

Section: Introductionmentioning

confidence: 99%

Plasma LncRNA-ATB, a Potential Biomarker for Diagnosis of Patients with Coal Workers’ Pneumoconiosis: A Case-Control Study

Cui

Rong

et al. 2016

IJMS

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LncRNA-ATB (lncRNA was activated by transforming growth factor-β) has been reported to be involved in specific physiological and pathological processes in human diseases, and could serve as biomarkers for cancers. However, the role of lncRNA-ATB in coal workers’ pneumoconiosis (CWP) is still unknown. This study aimed to investigate the association between lncRNA-ATB and CWP. Quantitative real-time polymerase chain reaction was performed to detect plasma lncRNA-ATB expression in 137 CWP patients, 72 healthy coal miners and 168 healthy controls. LncRNA-ATB was significantly upregulated in CWP (p < 0.05). Compared with the healthy controls and healthy coal miners, the odds ratios (ORs) (95% confidence interval (CI)) for CWP were 2.57 (1.52–4.33) and 2.17 (1.04–4.53), respectively. LncRNA-ATB was positively associated with transforming growth factor-β1 (TGF-β1) (r = 0.30, p = 0.003) and negative correlated with vital capacity (VC) (r = −0.18, p = 0.033) and forced vital capacity (FVC) (r = −0.18, p = 0.046) in CWP patients. Compared with healthy controls, the area under the curve (AUC) was 0.84, resulting in a 71.17% sensitivity and 88.14% specificity. When compared with healthy coal miners, the AUC was 0.83, the sensitivity and specificity were 70.07% and 86.36%, respectively. LncRNA-ATB expression is commonly increased in CWP and significantly correlates with the TGF-β1 in CWP patients. Furthermore, elevated lncRNA-ATB was associated with CWP risk and may serve as a potential biomarker for CWP.

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Downregulation of lncRNA-ATB correlates with clinical progression and unfavorable prognosis in pancreatic cancer

Cited by 54 publications

References 27 publications

Long non-coding RNA ATB promotes malignancy of esophageal squamous cell carcinoma by regulating miR-200b/Kindlin-2 axis

Long non-coding RNA ATB promotes malignancy of esophageal squamous cell carcinoma by regulating miR-200b/Kindlin-2 axis

Long Non-Coding RNAs: Key Regulators of Epithelial-Mesenchymal Transition, Tumour Drug Resistance and Cancer Stem Cells

Plasma LncRNA-ATB, a Potential Biomarker for Diagnosis of Patients with Coal Workers’ Pneumoconiosis: A Case-Control Study

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