Downregulation of LncRNA GAS5 promotes liver cancer proliferation and drug resistance by decreasing PTEN expression

Wang, Congren; Ke, Shao-Ying; Li, Mingzhu; Lin, Conglin; Liu, Xiaoyu; Qin, Pan

doi:10.1007/s00438-019-01620-5

Cited by 56 publications

(37 citation statements)

References 33 publications

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“…GAS5 has been implicated in multiple forms of cancers [158], and is a well-known tumor suppressor gene [159]. However, its multitude of roles in HCC has only recently been investigated [160][161][162]. Wang et.…”

Section: Tumor Suppressor Lncrnasmentioning

confidence: 99%

Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy

Mahpour

Mullen

2021

JHEP Reports

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Tumor Suppressor Lncrnasmentioning

confidence: 99%

Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy

Mahpour

Mullen

2021

JHEP Reports

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“…In the case of gastric cancer, five miRNAs have been reported to be related to GAS5 , miR-222 [ 99 ], miR-21 [ 100 , 101 ], miR-544 [ 102 ], miR-135b [ 103 ] and miR-34a [ 104 ]. GAS5 was shown to sensitize hepatocellular cancer cells to chemotherapy by sponging miR-222 [ 99 ].…”

Section: The Special Case Of Gas5 and Mirnasmentioning

confidence: 99%

“…GAS5 was shown to sensitize hepatocellular cancer cells to chemotherapy by sponging miR-222 [ 99 ]. Similarly, GAS5 directly acts as a sponge for miR-21, suppressing its expression and subsequently inhibiting hepatocellular carcinoma proliferation [ 100 , 101 ]. In the case of miR-544, GAS5 negatively regulates its expression, inhibiting tumor cell proliferation [ 102 ].…”

Section: The Special Case Of Gas5 and Mirnasmentioning

confidence: 99%

The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance

Lambrou

Hatziagapiou

Zaravinos

2020

IJMS

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The growth arrest-specific transcript 5 (GAS5) is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, we reviewed the current literature on the expression of GAS5 in leukemia, cervical, breast, ovarian, prostate, urinary bladder, lung, gastric, colorectal, liver, osteosarcoma and brain cancers, as well as its interaction with various miRNAs and its effect on therapy-related resistance in these malignancies. The general consensus is that GAS5 acts as a tumor suppressor across different tumor types and that its up-regulation results in tumor sensitization to chemotherapy or radiotherapy. GAS5 seems to play a previously unappreciated, but significant role in tumor therapy-induced resistance.

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“…Additionally, Wang et al documented that the downregulation of GAS5 enhanced cell proliferation and doxorubicin resistance of hepatocellular carcinoma through regulating the miR-21/PTEN signals. 35 Long et al announced the inhibitory effect of GAS5 on tumor development and stimulation of chemosensitivity of ovarian cancer was attributed to the GAS5-E2F4-PARP1-MAPK axis. 36 And GAS5 overexpression was recorded to increase the radiosensitivity of cervical cancer cells via the regulation of miR-106/IER3 and non-small cell lung cancer (NSCLC) cells through decreasing the level of miR-135b.…”

Section: Discussionmentioning

confidence: 99%

<p>Long Non-Coding RNA GAS5 Suppresses Tumor Progression and Enhances the Radiosensitivity of Prostate Cancer Through the miR-320a/RAB21 Axis</p>

Wang

Ren

et al. 2020

CMAR

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Background: Long non-coding RNAs (lncRNAs) function as a class of significant mediators in prostate cancer (PCa), and this study mainly discussed the molecular mechanism of lncRNA growth arrest-specific 5 (GAS5) in PCa progression and radiosensitivity. Materials and Methods: GAS5 and microRNA-320a (miR-320a) levels were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Cell viability and migration were severally examined through 3-(4, 5-dimethylthiazol-2-y1)-2, 5-diphenyl tetrazolium bromide (MTT) and transwell assays. PCa cells were treated with X-ray irradiation. Cell survival and apoptosis rate were assayed using colony formation assay and flow cytometry, respectively. The apoptosis-related protein and Rab GTPase 21 (RAB21) protein levels were measured by Western blot. The relation between miR-320a and GAS5 or RAB21 was assessed via the dual-luciferase reporter assay. The effect of GAS5 on radiosensitivity of PCa in vivo was evaluated by xenotransplantation assay. Results: GAS5 was down-regulated in PCa tissues and cells. GAS5 overexpression suppressed cell viability and migration while facilitated radiosensitivity of PCa cells. GAS5 was a molecular sponge of miR-320a. The effects of GAS5 up-regulation on PCa cells were accomplished by sponging miR-320a. MiR-320a targeted RAB21 and GAS5 up-regulated RAB21 expression via targeting miR-320a. RAB21 knockdown reversed the effects of miR-320a inhibition on PCa cells. GAS5 promoted the radiosensitivity of PCa by the miR-320a/RAB21 axis in vivo. Conclusion: Collectively, GAS5 restrained tumor development and expedited the radiosensitivity in PCa by the miR-320a/RAB21 axis, which provided a molecular regulatory mechanism of GAS5/miR-320a/RAB21 in PCa development and radioresistance.

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Downregulation of LncRNA GAS5 promotes liver cancer proliferation and drug resistance by decreasing PTEN expression

Cited by 56 publications

References 33 publications

Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy

Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy

The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance

<p>Long Non-Coding RNA GAS5 Suppresses Tumor Progression and Enhances the Radiosensitivity of Prostate Cancer Through the miR-320a/RAB21 Axis</p>

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