2020
DOI: 10.1111/1346-8138.15297
|View full text |Cite
|
Sign up to set email alerts
|

Downregulation of lysyl oxidase in venous malformations: Association with vascular destabilization and sclerotherapy

Abstract: Venous malformations (VM) are localized defects in vascular morphogenesis manifested by dilated venous channels with reduced perivascular cell coverage. As a vital enzyme for extracellular matrix (ECM) deposition, lysyl oxidase (LOX) plays important roles in vascular development and diseases. However, the expression and significance of LOX are unknown in VM. Herein, 22 VM specimens and eight samples of normal skin tissues were evaluated immunohistochemically for the expression of LOX, α-smooth muscle cell acti… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(1 citation statement)
references
References 39 publications
0
1
0
Order By: Relevance
“…Our results suggest that LOX expression is significantly higher in aged patients with venous reflux than in those without reflux, whereas LOXL-1 presents higher expression in young patients with reflux in comparison to young patients without reflux. LOX is an important marker of vascular integrity, and its expression levels seems to be directly correlated with different tissue markers like α-smooth muscle cell actin and the proper TGF-β [40]. LOXL-1 also shows a differential expression pattern related to the aging process [34].…”
Section: Discussionmentioning
confidence: 99%
“…Our results suggest that LOX expression is significantly higher in aged patients with venous reflux than in those without reflux, whereas LOXL-1 presents higher expression in young patients with reflux in comparison to young patients without reflux. LOX is an important marker of vascular integrity, and its expression levels seems to be directly correlated with different tissue markers like α-smooth muscle cell actin and the proper TGF-β [40]. LOXL-1 also shows a differential expression pattern related to the aging process [34].…”
Section: Discussionmentioning
confidence: 99%