Downregulation of MACC1 facilitates the reversal effect of verapamil on the chemoresistance to active metabolite of irinotecan in human colon cancer cells

Qian, Xiaotao; Zhang, Yongxin; Zhang, Tengyue; Fan, Pingsheng

doi:10.1016/j.heliyon.2022.e11294

Cited by 2 publications

(1 citation statement)

References 60 publications

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“…As an ATPase protein-binding factor, MACC1's; effect on adenosine triphosphate can boost ATP synthesis in tumor cells, the synthetic division of tumor cell spindles, and tumor cell proliferation[ 15 ]. Certain researchers have analyzed MACC1 expression in patients with colon cancer proposing that an elevated MACC1 positive expression rate may increase the risk of colon cancer[ 16 , 17 ]. On the other hand, studies on V-ATPase are sparse, with, most resorting to univariate analysis.…”

Section: Discussionmentioning

confidence: 99%

Correlation between the expressions of metastasis-associated factor-1 in colon cancer and vacuolar ATP synthase

He,

Cao,

Huang

et al. 2023

World J Gastrointest Surg

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BACKGROUND Clinical prognosis often worsens due to high recurrence rates following radical surgery for colon cancer. The examination of high-risk recurrence factors post-surgery provides critical insights for disease evaluation and treatment planning. AIM To explore the relationship between metastasis-associated factor-1 in colon cancer (MACC1) and vacuolar ATP synthase (V-ATPase) expression in colon cancer tissues, and recurrence rate in patients undergoing radical colon cancer surgery. METHODS We selected 104 patients treated with radical colon cancer surgery at our hospital from January 2018 to June 2021. Immunohistochemical staining was utilized to assess the expression levels of MACC1 and V-ATPase in these patients. RESULTS The rates of MACC1 and V-ATPase positivity were 64.42% and 67.31%, respectively, in colon cancer tissues, which were significantly higher than in paracancerous tissues (P < 0.05). Among patients with TNM stage III, medium to low differentiation, and lymph node metastasis, the positive rates of MACC1 and V-ATPase were significantly elevated in comparison to patients with TNM stage I-II, high differentiation, and no lymph node metastasis (P < 0.05). The rate of MACC1 positivity was 76.67% in patients with tumor diameters > 5 cm, notably higher than in patients with tumor diameters ≤ 5 cm (P < 0.05). We observed a positive correlation between MACC1 and V-ATPase expression (rs = 0.797, P < 0.05). The positive rates of MACC1 and V-ATPase were significantly higher in patients with recurrence compared to those without (P < 0.05). Logistic regression analysis revealed TNM stage, lymph node metastasis, MACC1 expression, and V-ATPase expression as risk factors for postoperative colon cancer recurrence (OR = 6.322, 3.435, 2.683, and 2.421; P < 0.05). CONCLUSION The upregulated expression of MACC1 and V-ATPase in colon cancer patients appears to correlate with clinicopathological features and post-radical surgery recurrence.

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Section: Discussionmentioning

confidence: 99%

Correlation between the expressions of metastasis-associated factor-1 in colon cancer and vacuolar ATP synthase

He,

Cao,

Huang

et al. 2023

World J Gastrointest Surg

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MACC1 revisited – an in-depth review of a master of metastasis

Schöpe,

Torke,

Kobelt

et al. 2024

Biomark Res

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Cancer metastasis remains the most lethal characteristic of tumors mediating the majority of cancer-related deaths. Identifying key molecules responsible for metastasis, understanding their biological functions and therapeutically targeting these molecules is therefore of tremendous value. Metastasis Associated in Colon Cancer 1 (MACC1), a gene first described in 2009, is such a key driver of metastatic processes, initiating cellular proliferation, migration, invasion, and metastasis in vitro and in vivo. Since its discovery, the value of MACC1 as a prognostic biomarker has been confirmed in over 20 cancer entities. Additionally, several therapeutic strategies targeting MACC1 and its pro-metastatic functions have been developed. In this review, we will provide a comprehensive overview on MACC1, from its clinical relevance, towards its structure and role in signaling cascades as well as molecular networks. We will highlight specific biological consequences of MACC1 expression, such as an increase in stem cell properties, its immune-modulatory effects and induced therapy resistance. Lastly, we will explore various strategies interfering with MACC1 expression and/or its functions. Conclusively, this review underlines the importance of understanding the role of individual molecules in mediating metastasis.

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Downregulation of MACC1 facilitates the reversal effect of verapamil on the chemoresistance to active metabolite of irinotecan in human colon cancer cells

Cited by 2 publications

References 60 publications

Correlation between the expressions of metastasis-associated factor-1 in colon cancer and vacuolar ATP synthase

Correlation between the expressions of metastasis-associated factor-1 in colon cancer and vacuolar ATP synthase

MACC1 revisited – an in-depth review of a master of metastasis

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