The MALAT1, a huge non-coding RNA, recently came to light as a multifaceted regulator
in the intricate landscape of breast cancer (BC) progression. This review explores the multifaceted
functions and molecular interactions of MALAT1, shedding light on its profound implications
for understanding BC pathogenesis and advancing therapeutic strategies. The article commences
by acknowledging the global impact of BC and the pressing need for insights into its
molecular underpinnings. It is stated that the core lncRNA MALAT1 has a range of roles in both
healthy and diseased cell functions. The core of this review unravels MALAT1's multifaceted role
in BC progression, elucidating its participation in critical processes like resistance, invasion, relocation,
and proliferating cells to therapy. It explores the intricate mechanisms through which
MALAT1 modulates gene expression, interacts with other molecules, and influences signalling
pathways. Furthermore, the paper emphasizes MALAT1's clinical significance as a possible prognostic
and diagnostic biomarker. Concluding on a forward-looking note, the review highlights the
broader implications of MALAT1 in BC biology, such as its connections to therapy resistance and
metastasis. It underscores the significance of deeper investigations into these intricate molecular
interactions to pave the way for precision medicine approaches. This review highlights the pivotal
role of MALAT1 in BC progression by deciphering its multifaceted functions beyond the genome,
offering profound insights into its implications for disease understanding and the potential for targeted
therapeutic interventions.
