Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells

Kang, Gum–Yong; Lee, Eung-Ryoung; Kim, Jung-Hyun; Jung, Jin Woo; Lim, Jun; Kim, Sang Kyung; Cho, Ssang-Goo; Kim, Kwang Pyo

doi:10.1016/j.ejphar.2009.03.068

Cited by 53 publications

(36 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Though the IC 50 values of morin and quercetin are much higher than the marine- and bacterial-originating compounds of scytonemin, staurosporine and wortmannin, these compounds may be of greater chemo-preventive interest due to their availability in plants. It should also be noted that the data with kaemperfol are inconsistent with data reported by Kang et al that a dose of 50 µM inhibits Plk1 in MCF-7 cells (63). Thus, kaemperfol may reduce Plk1 protein levels; however, the dose used appears to be very cytotoxic (98% sub-G 1 ) and may also be a consequence of the large amount of cell death and not a direct inhibition of Plk1 (63).…”

Section: Negative Regulation Of Plk1 By Natural Agents: Plk1 As a Tarcontrasting

confidence: 70%

Modulating Polo-Like Kinase 1 as a Means for Cancer Chemoprevention

2010

View full text Add to dashboard Cite

Naturally occurring agents have always been appreciated for their medicinal value for both their chemopreventive and therapeutic effects against cancer. In fact, the majority of the drugs we use today, including the anti-cancer agents, were originally derived from natural compounds, either in their native form or modified to enhance their bioavailability or specificity. It is believed that for maximum effectiveness, it will useful to design novel target-based agents for chemoprevention as well as the treatment of cancer. Recent studies have shown that the serine/threonine kinase polo-like kinase (Plk) 1 is widely overexpressed in a variety of cancers and is being increasingly appreciated as a target for cancer management. Additionally, several chemopreventive agents have been shown to inhibit Plk1 in cancer cells. In this review, we will discuss if Plk1 could also be a target for designing novel strategies for cancer chemoprevention.

show abstract

Section: Negative Regulation Of Plk1 By Natural Agents: Plk1 As a Tarcontrasting

confidence: 70%

Modulating Polo-Like Kinase 1 as a Means for Cancer Chemoprevention

2010

View full text Add to dashboard Cite

show abstract

“…Kaempferol is a flavonoid that reduces the cell viability of breast cancer cells by inducing ROS mediated apoptosis and ERK activation as demonstrated by 3D culture conditions 135,136. On the other hand, Acacetin, which is a natural flavone, and stimulate apoptosis in MCF-7, breast cancer cells that is mediated by activation of caspases, ROS generation, mitochondria-mediated cell death signaling and the induction of SAPK/JNK1/2-c-Jun signaling pathway 137.…”

Section: Oxidative Stress Signaling Through Map Kinasesmentioning

confidence: 99%

Redox Regulation in Cancer: A Double‐edged Sword with Therapeutic Potential

Acharya

Das

Chandhok

et al. 2009

Oxidative Medicine and Cellular Longevity

426

300

View full text Add to dashboard Cite

Oxidative stress, implicated in the etiology of cancer, results from an imbalance in the production of reactive oxygen species (ROS) and cell’s own antioxidant defenses. ROS deregulate the redox homeostasis and promote tumor formation by initiating an aberrant induction of signaling networks that cause tumorigenesis. Ultraviolet (UV) exposures, γ-radiation and other environmental carcinogens generate ROS in the cells, which can exert apoptosis in the tumors, thereby killing the malignant cells or induce the progression of the cancer growth by blocking cellular defense system. Cancer stem cells take the advantage of the aberrant redox system and spontaneously proliferate. Oxidative stress and gene-environment interactions play a significant role in the development of breast, prostate, pancreatic and colon cancer. Prolonged lifetime exposure to estrogen is associated with several kinds of DNA damage. Oxidative stress and estrogen receptor-associated proliferative changes are suggested to play important roles in estrogen-induced breast carcinogenesis. BRCA1, a tumor suppressor against hormone responsive cancers such as breast and prostate cancer, plays a significant role in inhibiting ROS and estrogen mediated DNA damage; thereby regulate the redox homeostasis of the cells. Several transcription factors and tumor suppressors are involved during stress response such as Nrf2, NFκB and BRCA1. A promising strategy for targeting redox status of the cells is to use readily available natural substances from vegetables, fruits, herbs and spices. Many of the phytochemicals have already been identified to have chemopreventive potential, capable of intervening in carcinogenesis.

show abstract

“…1A), the retention time (RT) of peaks 1, 2 and 3 were matched to the RT values and absorption maxima of standards, chrysin, quercetin and kaempferol, respectively ( Supplementary Fig.2). It was also reported that kaempferol induces apoptosis in MCF-7 cells (Kang et al, 2009). Chrysin, a flavonoid has also been reported to induce apoptosis in various cancer cells and inhibit metastasis in triple negative breast cancer cells (Yang et al, 2014).…”

Section: Hplc Analysismentioning

confidence: 94%