Downregulation of Retinal Connexin 43 in GFAP-Expressing Cells Modifies Vasoreactivity Induced by Perfusion Ocular Pressure Changes

Liu, Guodong; Li, Hui; Cull, Grant; Wilsey, Laura J; Yang, Hongli; Reemmer, Jesica; Shen, Hai‐Ying; Wang, Fang; Fortune, Brad; Bui, Bang V.; Wang, Lin

doi:10.1167/iovs.62.1.26

Cited by 2 publications

(1 citation statement)

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“…Such coordination is important for maintaining sufficient blood flow, and thus nutrient delivery, in the face of challenges to perfusion. In the eye, targeted miRNA knockdown of glial Cx43 expression compromises the reactivity of both arterioles and venules to challenges to ocular perfusion [49]. Regulation of central nervous system blood flow is a key function and an important mechanism for supporting neuronal metabolism during the changing balance between metabolic supply and demand.…”

Section: The Astrocyte Neuron Lactate Shuttlementioning

confidence: 99%

Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration

Boal

Risner

Cooper

et al. 2021

Cells

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Astrocytes are intimately involved in the response to neurodegenerative stress and have become an attractive target for the development of neuroprotective therapies. However, studies often focus on astrocytes as single-cell units. Astrocytes are densely interconnected by gap junctions that are composed primarily of the protein connexin-43 (Cx43) and can function as a broader network of cells. Such networks contribute to a number of important processes, including metabolite distribution and extracellular ionic buffering, and are likely to play an important role in the progression of neurodegenerative disease. This review will focus on the pro-degenerative and pro-survival influence of astrocyte Cx43 in disease progression, with a focus on the roles of gap junctions and hemichannels in the spread of degenerative stress. Finally, we will highlight the specific evidence for targeting these networks in the treatment of glaucomatous neurodegeneration and other optic neuropathies.

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Section: The Astrocyte Neuron Lactate Shuttlementioning

confidence: 99%