2023
DOI: 10.1002/iid3.803
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Downregulation of ROR2 attenuates LPS‐induced A549 cell injury through JNK and ERK signaling pathways

Abstract: Background: We aimed to determine whether receptor tyrosine kinase-like orphan receptor 2 (ROR2) is involved in the occurrence of acute lung injury (ALI) by an animal study and explore the effect of ROR2 downregulation on lipopolysaccharide (LPS)-treated human lung carcinoma A549 cells by a cytological study.Methods: Murine models of ALI were successfully constructed by intratracheal instillation of LPS. Meanwhile, A549 cell line stimulated with LPS was used for a cytological study. The expression of ROR2 and … Show more

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