Downregulation of SOX11 in fetal heart tissue, under hyperglycemic environment, mediates cardiomyocytes apoptosis

Su, Dongmei; Gao, Qianqian; Guan, Lina; Li, Qian; Shi, Cuige; Ma, Xu

doi:10.1002/jbt.22629

Cited by 8 publications

(5 citation statements)

References 26 publications

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“…Both in vivo and clinical studies have proven that cardiac apoptosis plays a major role in the regressed function of the heart in diabetic conditions, mainly induced and derived from a high glucose level [ 55 , 56 , 57 ]. Caspases are a family of inactive proenzymes that play an important role in apoptosis.…”

Section: Diabetic Cardiomyopathy: Understanding the Cardiac Oxidative Stress Inflammation And Apoptosis-related Pathophysiology And Pathomentioning

confidence: 99%

The Potential Role of Flavonoids in Ameliorating Diabetic Cardiomyopathy via Alleviation of Cardiac Oxidative Stress, Inflammation and Apoptosis

Jubaidi

Zainalabidin

Taib

et al. 2021

IJMS

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Diabetic cardiomyopathy is one of the major mortality risk factors among diabetic patients worldwide. It has been established that most of the cardiac structural and functional alterations in the diabetic cardiomyopathy condition resulted from the hyperglycemia-induced persistent oxidative stress in the heart, resulting in the maladaptive responses of inflammation and apoptosis. Flavonoids, the most abundant phytochemical in plants, have been reported to exhibit diverse therapeutic potential in medicine and other biological activities. Flavonoids have been widely studied for their effects in protecting the heart against diabetes-induced cardiomyopathy. The potential of flavonoids in alleviating diabetic cardiomyopathy is mainly related with their remedial actions as anti-hyperglycemic, antioxidant, anti-inflammatory, and anti-apoptotic agents. In this review, we summarize the latest findings of flavonoid treatments on diabetic cardiomyopathy as well as elucidating the mechanisms involved.

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Section: Diabetic Cardiomyopathy: Understanding the Cardiac Oxidative Stress Inflammation And Apoptosis-related Pathophysiology And Pathomentioning

confidence: 99%

The Potential Role of Flavonoids in Ameliorating Diabetic Cardiomyopathy via Alleviation of Cardiac Oxidative Stress, Inflammation and Apoptosis

Jubaidi

Zainalabidin

Taib

et al. 2021

IJMS

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“…Moreover, SOX11 is reportedly essential for the pulmonary inflammatory response 40 , and SOX11 knockout mice demonstrated serious developmental defects, including defects related to the heart, spleen generation, skeletal development, and the development of the anterior ophthalmic ganglion 41 . Lastly, Su et al 20 identified that SOX11 overexpression represses apoptosis in cardiomyocytes after hyperglycemia treatment. In our study, SOX11 was upregulated in cardiac fibrosis samples.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, defective expression of SOX11 caused malformations in various human organs and systems, including the lungs, heart, and skeletal and gastrointestinal systems 19 . A recent study showed that SOX11 downregulation in fetal heart tissue mediated cardiomyocyte apoptosis 20 .…”

Section: Introductionmentioning

confidence: 99%

JAZF1 is transcriptionally regulated by SOX11 and promotes cardiac fibrosis by PI3K-Akt pathway

Mo,

Wang,

Liang

et al. 2023

Preprint

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Cardiac fibrosis is a component of all chronic heart diseases. JAZF1 regulates metabolism through various mechanisms; however, its role in cardiac fibrosis remains unclear. We aimed to investigate the role of JAZF1 in cardiac fibrosis. A rat cardiac fibrosis model was established by administering isoproterenol subcutaneously for 14 days (5 mg/kg/day); an equal volume of saline was administered to the control group. Cardiac fibroblasts were treated with TGF-β1 for 48 h to mimic cardiac fibrosis in vitro. JAZF1 expression at the protein and mRNA levels was enhanced in CFs and cardiac fibrosis tissues. JAZF1 downregulation suppressed CFs' proliferation and migration. Western blotting showed that the PI3K/Akt signaling pathway was significantly decreased after JAZF1 knockdown. Further experiments revealed that SOX11 is an important transcription factor whose overexpression and downregulation enhanced and suppressed JAZF1 levels, respectively. Luciferase analysis showed that SOX11 interacted with the JAZF1 promoter. Moreover, SOX11 promoted cardiac fibrosis by regulating JAZF1 expression. JAZF1 was enhanced in cardiac fibrosis tissue and TGF-β-treated CFs. JAZF1 knockdown decreased CFs' migration and proliferation, possibly remediated by SOX11 with activation of PI3k/Akt signaling pathways.

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“…GO analysis showed that SOX11 expression was positively enriched in gene regulatory mechanisms as well as multiple immune response pathways, while SOX11 expression was negatively enriched in the regulation of cell cycle G1/S transition, epidermal cell growth, epidermal cell differentiation and epithelial migration. SOX11 has been reported to affect apoptosis-associated cell survival pathways, TEAD2 transcriptional activity, mitosis and immune-inflammatory responses [ 15 , 48 , 64 ]. It has also been shown that SOX11 may be associated with specific key pathways related to certain developmental processes, including the WNT signaling pathway and the TCF/β-linked protein complex in hepatocellular carcinoma [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Systematic Investigation of the Multifaceted Role of SOX11 in Cancer

Sun

Dong

et al. 2022

Cancers

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SRY-box transcription factor 11 (SOX11), as a member of the SOX family, is a transcription factor involved in the regulation of specific biological processes and has recently been found to be a prognostic marker for certain cancers. However, the roles of SOX11 in cancer remain controversial. Our study aimed to explore the various aspects of SOX11 in pan-cancer. The expression of SOX11 was investigated by the Genotype Tissue-Expression (GTEX) dataset and the Cancer Genome Atlas (TCGA) database. The protein level of SOX11 in tumor tissues and tumor-adjacent tissues was verified by human pan-cancer tissue microarray. Additionally, we used TCGA pan-cancer data to analyze the correlations among SOX11 expression and survival outcomes, clinical features, stemness, microsatellite instability (MSI), tumor mutation burden (TMB), mismatch repair (MMR) related genes and the tumor immune microenvironment. Furthermore, the cBioPortal database was applied to investigate the gene alterations of SOX11. The main biological processes of SOX11 in cancers were analyzed by Gene Set Enrichment Analysis (GSEA). As a result, aberrant expression of SOX11 has been implicated in 27 kinds of cancer types. Aberrant SOX11 expression was closely associated with survival outcomes, stage, tumor recurrence, MSI, TMB and MMR-related genes. In addition, the most frequent alteration of the SOX11 genome was mutation. Our study also showed the correlations of SOX11 with the level of immune infiltration in various cancers. In summary, our findings underline the multifaceted role and prognostic value of SOX11 in pan-cancer.

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Downregulation of SOX11 in fetal heart tissue, under hyperglycemic environment, mediates cardiomyocytes apoptosis

Cited by 8 publications

References 26 publications

The Potential Role of Flavonoids in Ameliorating Diabetic Cardiomyopathy via Alleviation of Cardiac Oxidative Stress, Inflammation and Apoptosis

The Potential Role of Flavonoids in Ameliorating Diabetic Cardiomyopathy via Alleviation of Cardiac Oxidative Stress, Inflammation and Apoptosis

JAZF1 is transcriptionally regulated by SOX11 and promotes cardiac fibrosis by PI3K-Akt pathway

Systematic Investigation of the Multifaceted Role of SOX11 in Cancer

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