2015
DOI: 10.1038/cddis.2015.250
|View full text |Cite
|
Sign up to set email alerts
|

Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome

Abstract: Alterations in the scaffold protein WRAP53β have previously been linked to carcinogenesis and, in particular, associated with an increased risk for epithelial ovarian cancer. Here, we investigated the pathogenic impact and prognostic significance of WRAP53β in connection with epithelial ovarian cancer and examined the underlying mechanisms. We find that reduced expression of WRAP53β in ovarian tumors correlated with attenuated DNA damage response and poor patient survival. Furthermore, in ovarian cancer cell l… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

1
37
1

Year Published

2016
2016
2023
2023

Publication Types

Select...
6

Relationship

1
5

Authors

Journals

citations
Cited by 27 publications
(39 citation statements)
references
References 41 publications
1
37
1
Order By: Relevance
“…3, 4 Examination of western blots with either of these antibodies revealed elevated expression of WRAP53 β (Figure 1a). …”
Section: Resultsmentioning
confidence: 99%
See 3 more Smart Citations
“…3, 4 Examination of western blots with either of these antibodies revealed elevated expression of WRAP53 β (Figure 1a). …”
Section: Resultsmentioning
confidence: 99%
“…In contrast, WRAP53 β is recruited to sites of DNA damage from the nuclear pool alone, that is, no cytoplasmic shuttling is involved. 4 In addition, many repair factors are bound to chromatin even before damage, allowing rapid redistribution to damaged sites when needed.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Functionally, WDR79 serves as a scaffold protein through the β‐propeller platform structure formed by WD‐repeat domains and is involved in telomerase assembly, Cajal body formation and DNA double stand break repair 3, 4, 5, 6, 7, 8. Emerging studies have shown that aberrations in WDR79 expression correlate with many different malignancies, such as rectal cancer,9 head and neck carcinomas,10 oesophageal squamous cell carcinoma,11 breast cancer,12 ovarian cancer 13 and nasopharyngeal carcinoma 14. Our previous studies revealed that WDR79 is frequently overexpressed in cell lines and tissues derived from non‐small cell lung cancer and promotes the proliferation of NSCLC cells,15, 16 which is consistent with a recent study 17.…”
Section: Introductionmentioning
confidence: 99%