Downregulation of the long noncoding RNA DSCR9 (Down syndrome critical region 9) delays breast cancer progression by modulating microRNA-504-5p-dependent G protein-coupled receptor 65

Identification of survival related key genes and long-term survival specific differentially expressed genes related key miRNA network of primary glioblastoma

“…miR-6817-3p stabilizes Wnt2B through the mechanism of ceRNA combined with AC104041.1, thereby exerting anticancer effects [ 36 ]; miR-6833-3p regulates the tumorigenesis effect of colorectal through the LINC-ROR/miR-6833-3p/SMC4 axis [ 37 ]; miR-6809-3p, miR-6829-3p, and miR-6804-5p are one of the miRs targeting overexpressed genes in lung cancer [ 38 ]; miR-7107-5p and miR-6891-5p are one of the markers identified in endoscopic cholangiopancreatography for the treatment of bile in malignant biliary strictures [ 39 ]; miR-1910-3p in exosomes activates NF-kB pathway through MTMR3 to promote proliferation, metastasis and autophagy in breast cancer [ 40 ]; The miR198-CUL4B pathway mediates circMFN2 induced glycolysis in ovarian cancer and has sensitization effect in gemcitabine treatment of pancreatic cancer [ 41 , 42 ]; miR-4446-3p was found in the serum of colon adenocarcinoma patients and has diagnostic value [ 43 ]; miR-6894-5p promotes gastric cancer progression through the activation of circAFF2 [ 44 ]; miR-6794-5p participates in constructing a large-scale microRNA map detection model for esophageal squamous cell carcinoma [ 45 ]; miR-197-5p adsorbed by circ0125803 in glioblastoma can lead to tumor progression and it increases the anticancer cytotoxicity of HT1080 fibrosarcoma cells mediated by doxorubicin by reducing drug efflux [ 46 , 47 ]; miR-6795-5p is an important component of LINC01013-miR-6795-5p-FMNL3 axis regulation of liver cancer stem cell characteristics [ 48 ]; miR-3154 is one of the potential prognostic biomarkers for cervical cancer and it is one of the potential prognostic biomarkers for cervical cancer [ 49 , 50 ]; miR-936 mediates cell proliferation and invasion in glioma through the miR-936/ERBB4 axis and it mediate the acquisition of non androgen dependent prostate cancer metastasis phenotype when it lossed. It also targeting GPR78 to regulate chemotherapy resistance in non-small cell lung cancer [ 51 ]; Down regulation of lincRNA DSCR9 delays breast cancer progression by regulating microRNA-504-5p-dependent G-protein-coupled receptor 65 [ 52 ]; The content of miR-6127 significantly increased in extracellular vesicles of metastatic colorectal cancer cell lines intervened by rapamycin [ 53 ]; EWI-2, located on the cell membrane and extracellular vesicles of miR-3934-5p, is a key molecule that regulates the distribution of miR-3934-5p and has the function of inhibiting prostate cancer cell metastasis [ 54 ]. In addition, miR-4713-3p is the most important miR that affects the expression of EPHX3 gene in head and neck squamous cell carcinoma, often leading to poor prognosis and tumor immune infiltration [ 55 ].…”

Resistance and aerobic training increases genome-wide DNA methylation in women with polycystic ovary syndrome

“…Overexpression of the lncRNA SNHG5 is related to the carcinogenesis process and metastasis [ 63 ], and downregulation of the SNHG5 May be associated with triglycerides and T2DM susceptibility [ 64 , 65 ]. The lncRNA DSCR9, Down syndrome (DS) critical regions (DSCRs) are responsible for most features of DS, including metabolic disease and insulin regulation [ 66 ], and are associated with cancer progression [ 67 ]. These changes in DNA methylation levels in specific CpG contexts and chromosomal regions in combination contribute to the hormonal, metabolic, and anthropometric changes observed after aerobic and resistance exercise [ 61 , 62 ].…”