Downregulation of the transforming growth factor-β/connective tissue growth factor 2 signalling pathway in venous malformations: its target potential for sclerotherapy

Ren, Jian‐Gang; Chen, G.; Zhu, Junyi; Zhang, W.; Sun, Yanfang; Jia, Jun; Zhang, J.; Zhao, Yi‐Fang

doi:10.1111/bjd.12977

Cited by 27 publications

(36 citation statements)

References 47 publications

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“…According to previous studies, 25 The results also showed that Fra-1 (P < 0.001), c-Jun (P < 0.001) and c-Fos (P < 0.001) were up-regulated in OKC samples when compared with OM and DC specimens ( Figure 1C). All these results showed the elevated protein and mRNA levels of Fra-1, c-Jun and c-Fos in OKCs.…”

Section: H I E R a R C H I C A L C L U S T E R I N G V I S U A L I supporting

confidence: 80%

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Overexpression of Fra‐1, c‐Jun and c‐Fos in odontogenic keratocysts: potential correlation with proliferative and anti‐apoptotic activity

et al. 2018

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Section: H I E R a R C H I C A L C L U S T E R I N G V I S U A L I supporting

confidence: 80%

“…According to previous studies, Cluster 3.0 with average linkage based on Pearson's correlation coefficient was used for hierarchical analysis, and the results were visualised using Java TreeView version 1.0.5.…”

Section: Methodsmentioning

confidence: 99%

Overexpression of Fra‐1, c‐Jun and c‐Fos in odontogenic keratocysts: potential correlation with proliferative and anti‐apoptotic activity

et al. 2018

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“…Blood sampling displays coagulation disorder in more than 50% of patients. Elevated D-Dimer plasma levels and von Willebrand Factor can be found, indicating localized intravascular coagulopathy (LIC) with increased endothelial dysfunction markers, venous stasis and inflammation [30], [31]. On ultrasound VMs are hypoechogenic tubular structures with slow flow pattern and occasionally increased surrounding fatty tissue [32].…”

Section: Resultsmentioning

confidence: 99%

Interdisciplinary Management of Head and Neck Vascular Anomalies: Clinical Presentation, Diagnostic Findings and Minimalinvasive Therapies

Sadick

Wohlgemuth

Huelse

et al. 2017

European Journal of Radiology Open

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ObjectivesVascular anomalies are included in the 30 000 rare diseases worldwide affecting less than 5/10 000 people. Depending on their morphology and biological properties, they can cause varied disorders with organ involvement. Almost 60% of vascular anomalies have a predilection for the head and neck region in children. Clinical and scientific effort to establish interdisciplinary management concepts for vascular anomalies is increasing worldwide.MethodsEspecially in the head and neck region, clinical impairment and organ dysfunction is associated with cosmetic issues that may represent a physical and psychological issue for the patient. Correct diagnosis, based on clinical presentation and symptoms, is a prerequisite for appropriate therapy, ranging from conservative management to a spectrum of minimally invasive treatment options. We searched PubMed for German and English language published data until December 2016 with focus on clinical studies, review articles and case reports on vascular anomalies with a focus on the head and neck region.ResultsThe last ISSVA update in 2014 has contributed to a better understanding of vascular anomalies, classifying them in vascular tumors and vascular malformations. The predominant representatives of vascular tumors are congenital and infantile hemangiomas. Infantile hemangiomas have the ability of spontaneous regression in more than 80%. Patients with symptomatic growing hemangiomas with ulcerations, bleeding complications and restriction of hearing, swallowing disorder, impairment of vision, or cosmetic dysfigurement require treatment. Therapies include oral propanolol, transcatheter embolization and surgery. Vascular malformations tend to progress with patientś age and are subdivided in slow flow and fast flow lesions. Symptomatic slow flow lesions, e.g. venous and lymphatic malformations, benefit from percutaneous sclerotherapy. Fast flow lesions, as arteriovenous malformations, are rare but undoubtedly therapeutically the most challenging vascular anomaly. Depending on location and size, they may require multiple transcatheter embolization procedures for successful occlusion of the AVM.ConclusionsThis review provides knowledge on the current ISSVA classification of vascular anomalies, their clinical presentation, diagnostic evaluation and minimally invasive therapy options to encourage the establishment of a comprehensive interdisciplinary management for head and neck vascular anomalies.

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“…The potentially negative relationship between connexins Cx43 and Cx32 and PCNA, cyclin D1, Bcl‐2, LC3 or p62 in the epithelial component of KCOT was reflected by double‐labelling immunofluorescence. The procedures were performed as described previously …”

Section: Methodsmentioning

confidence: 99%

Down‐regulation of connexin43 and connexin32 in keratocystic odontogenic tumours: potential association with clinical features

et al. 2015

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Downregulation of the transforming growth factor-β/connective tissue growth factor 2 signalling pathway in venous malformations: its target potential for sclerotherapy

Abstract: This study unmasks the downregulation of the TGF-β/CCN2 pathway in VMs, and indicates its target potential for sclerotherapy.

Cited by 27 publications

References 47 publications

Overexpression of Fra‐1, c‐Jun and c‐Fos in odontogenic keratocysts: potential correlation with proliferative and anti‐apoptotic activity

Overexpression of Fra‐1, c‐Jun and c‐Fos in odontogenic keratocysts: potential correlation with proliferative and anti‐apoptotic activity

Interdisciplinary Management of Head and Neck Vascular Anomalies: Clinical Presentation, Diagnostic Findings and Minimalinvasive Therapies

Down‐regulation of connexin43 and connexin32 in keratocystic odontogenic tumours: potential association with clinical features

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