The problem of PM2.5 pollution is a major concern in both Vietnam and around the world, with adverse effects on human health, animals, and the environment. It is crucial to monitor PM2.5 levels regularly on a large scale to assess air pollution and develop effective solutions. Besides, fine particulate matter (PM2.5) mapping at high resolution can have significance in studying pollution at a small scale. Nevertheless, most current researches on high-resolution PM2.5 mapping depend on high-resolution aerosol optical depth products. In this study, we propose a method to enhance the spatial resolution of low-resolution (3km) PM2.5 products and improve the quality of model output. The proposed method utilized a machine learning-based downscaling approach to generate high-resolution (1km) PM2.5 maps for Ho Chi Minh City in 2021. We also incorporated additional data sources such as meteorological data and land use information to improve the accuracy of the products. The proposed method was evaluated through numerical experiments, and the results showed a significant enhancement of the spatial resolution of PM2.5 products, from 3km to 1km and improved the accuracy of the output. Four models were trained and validated using data collected from 2018 to 2021. Catboost model yielded the best results in terms of predictive power with a Pearson R of 0.80, RMSE of 6.46 µg/m3, and MRE of 0.21 out of 2891 samples. The aggregated monthly and annual average maps of PM2.5 concentration in Ho Chi Minh City in 2021 exhibited exceptional quality compared to the 3km-resolution PM2.5 product. These concentration maps effectively depicted the spatial distribution and seasonal variations of PM2.5 in Ho Chi Minh City.