1994
DOI: 10.1016/0360-3016(94)90532-0
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Downstaging of advanced rectal cancer following combined preoperative chemotherapy and high dose radiation

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Cited by 166 publications
(31 citation statements)
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“…According to Heald et al [21], this is the case when the tumor has reached the mesorectal fascia [9]. These patients should be referred to neoadjuvant treatment modalities [8,14,32,40,41,48]. Thin-slice MRI can provide excellent information about the local extension of rectal cancer and its relation to the mesorectal fascia [4,5,30], but need further evaluation.…”
Section: Discussionmentioning
confidence: 99%
“…According to Heald et al [21], this is the case when the tumor has reached the mesorectal fascia [9]. These patients should be referred to neoadjuvant treatment modalities [8,14,32,40,41,48]. Thin-slice MRI can provide excellent information about the local extension of rectal cancer and its relation to the mesorectal fascia [4,5,30], but need further evaluation.…”
Section: Discussionmentioning
confidence: 99%
“…Recenti studi randomizzati europei hanno dimostrato un ulteriore miglioramento dei risultati clinici nei pazienti con cancro rettale extraperitoneale che sono trattati con radio e chemioterapia (5-FU/folato) pre-operatoria rispetto alla sola radioterapia convenzionale. Invece, l'associazione pre-operatoria di radioterapia + poli-chemioterapia (associazioni di 5-FU/ folato + oxaliplatino) non sembra aver dimostrato vantaggi rispetto all'associazione radioterapia + chemioterapia (5-FU/folato) pre-operatoria [47][48][49][50][51][52].…”
Section: Trattamento Del Carcinoma Del Colon-retto Negli Stadi Non Meunclassified
“…Delivery of radiotherapy (RT) as a short course followed by total mesorectal excision (TME) surgery has been favored by the Dutch Colorectal Cancer Group [8]. However, there are strong arguments in favor of delivering RT as a long course with a delay between the end of RT and definitive surgery [9]. Surgery has conventionally been performed in those deemed operable at approximately 6 weeks after completion of CRT, but it is unclear whether this is the optimum time for surgery.…”
Section: Introductionmentioning
confidence: 99%
“…Two patients (7.6%) developed local recurrence (median follow up, 34 months). The median time interval between radiotherapy and surgery was 11 (range, [7][8][9][10][11][12][13] weeks, which was based on serial MRI scans after LCRT. Conclusions Laparoscopic TME after LCRT is feasible and safe both oncologically and surgically.…”
Section: Introductionmentioning
confidence: 99%