Downstream effects: Impact of antibiotic pollution on an aquatic host–parasite interaction

Melchiorre, Hannah G.; Gutierrez, Stephanie O; Minchella, Dennis J.; Vannatta, J. Trevor

doi:10.1002/ecs2.4513

Cited by 3 publications

(2 citation statements)

References 49 publications

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“…Завдяки високій гідрофільності і низькій леткості тетрацикліни є стійкими у водному середовищі. Зазвичай концентрація тетрациклінів, які попадають у водойми складає 50 мкг/л (Melchiorre et al, 2023). Наприклад, у США зафіксовано концентрації у стічних водах в межах від 0,32 до 48 мкг/л, але в Китаї у стічних водах фармацевтичних підприємств виявлено до 129,3 мкг/л залишків (Xu et al, 2021).…”

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“…Враховуючи людські втрати від шистосомозу, використання антибіотиків у медицині та сільському господарстві (Faleye et al, 2018), експериментально проведені дослідження аналізу впливу тетрацикліну, на Schistosoma mansonі та його господаря-равлика (Melchiorre et al, 2023). Результати дослідження засвідчили, що тетрациклін сприяв розмноженню паразитів в інфікованих господарях і збільшував кількість паразитів по мірі розвитку інфекції.…”

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Safety of Tetracyclines for Public Health and the Environment

Kosenko,

Ostapiv,

Zaruma

2024

SCIVP

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Antimicrobial veterinary medicinal products of the tetracycline class have been most widely used for many years in the veterinary practice, both in Ukraine and in European countries, the USA, Canada, etc. Teteracyclynes have a wide-spectrum activity against gram-positive and gram-negative microorganisms, rickettsia, mycoplasma, chlamydia and protozoan parasites and are successfully used for the treatment of infectious diseases of the gastrointestinal tract, respiratory organs, skin and urogenital infections. Antimicrobial veterinary medicinal products of this class belong to AMEG category D, which is the safest in terms of impact on public health. Tetracyclines are low cost agents, are not high toxic when used in animals, which justifies their frequent choice for empirical treatment. During the monitoring of sales volumes for 2016-2021, antimicrobial veterinary medicinal products of the tetracycline class occupied the largest share among all antimicrobials entering the market in Ukraine (25.9-39.4)%. Most frequently, these veterinary medicinal products are intended for oral administration, but since their low bioavailability (5-15)%, they are excreted from the body almost unchanged. However, there is a danger of the development of tetracyclines resistance and a hazard to the environment and public health, which is explained by the frequent use of this class substances, the permission of large amounts into the soil with manure and water following drinkers washing after the treatment. Tetracyclines are poorly metabolized, and their long-term use in veterinary practice contributes to the bioaccumulation of significant amounts in soil and water. The main goal of this study were the analysis of veterinary medicinal products containing tetracyclines which were authorized in Ukraine by the category of active substances and route of administration. Another problem of this article was to substantiate the impact of tetracycline class antibiotics on the environment and the acquired antimicrobial resistance in the view of the necessity of their reasonable and safety use for the animals treatment, taking into account the requirements of the current legislation in Ukraine and EU member states. The results of the study proved that antimicrobial veterinary medicinal products containing chlortetracycline, mainly for oral administration, prevail in Ukraine. The bias of this monitoring is the lack information on the volumes of their use in farms and for individual animal species. Although the tetracycline class antibiotics do not belong to persistent bio accumulative toxic substances (PBT), their long-term and widespread use causes concern in view of the possible acquiring antimicrobial resistance and harmful effects on the environment, which will have an impact on public health. It is necessary to introduce regulatory measures to limitation and optimal use of these compounds in veterinary medicine. It is also necessary to deliver information among stakeholders about the possible negative impact on the environment and plan activities to prevent the development of acquired antimicrobial resistance to the tetracycline class antibiotics.

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Safety of Tetracyclines for Public Health and the Environment

Kosenko,

Ostapiv,

Zaruma

2024

SCIVP

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Limited Impact of Schistosome Infection onBiomphalaria glabrataSnail Microbiomes

Nordmeyer,

Anderson,

Chevalier

et al. 2024

Preprint

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Background: The microbiome of disease vectors can be a key determinant of their ability to transmit parasites. Conversely, parasite infection may modify vector microbiomes. We are exploring the interactions between the Biomphalaria glabrata snail microbiome and the blood fluke Schistosoma mansoni, responsible for an estimated 200,000 human deaths each year. Snail hosts vary in their susceptibility to schistosome parasites, and the underlying mechanisms driving this variation are not fully understood. We have previously shown that the snail hemolymph (i.e., blood) and organs harbor a diverse microbiome. Here we investigate the impact of schistosome infection on snail microbiomes, hypothesizing that invading schistosomes can alter the snail microbiomes in both composition and abundance over the course of infection, as developing schistosome parasites are in close contact with the host tissues. Results: We generated cohorts of uninfected and S. mansoni infected snails. We collected snail hemolymph and hepatopancreas (i.e., liver) at 8 timepoints during the pre-patent and patent periods of schistosome infection. We quantified bacterial density using qPCR and profiled the microbiome composition of all samples by sequencing the V4 region of the 16S rRNA. Schistosome infection had surprisingly no effect on bacterial density and limited effect on the microbiome composition, affecting mainly the hemolymph during the pre-patent period (at day 7 and 21). Organ and hemolymph microbiomes were relatively stable overtime for both infected and uninfected snail cohorts. The sample type (hemolymph, hepatopancreas) was the major driver of the differences observed in microbiome composition. Conclusions: The limited impact of schistosome infection on the host snail microbiomes might be explained by the long-term interaction of the two partners and the fact that parasite fitness is closely dependent on host fitness. Further investigations into the interactions between snails, their microbiomes, and schistosome parasites are essential for developing strategies to disrupt the parasite lifecycle and, consequently, schistosomiasis transmission.

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Contaminated freshwater as a Harbinger of tropical disease spread in Europe

Costa,

Guerrero,

Sureau

et al. 2024

Front. Environ. Sci.

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Human-induced environmental changes, including climate change and pollution, significantly affect host-parasite interactions, potentially altering the geographical spread and severity of various parasitic diseases. These changes may particularly influence the dynamics of diseases like schistosomiasis, posing significant public health concerns. This review explores how pollutants such as organophosphate pesticides, antibiotics, heavy metals, cities’ landfills, and microplastics can affect the development and transmission dynamics of parasites, especially Schistosoma spp. Our researches highlight that pesticides promote parasitic disease development, while pharmaceuticals have mixed effects on the life cycles of these parasites. Similarly, heavy metals found in water systems disrupt host-pathogen interactions, and microplastics are linked to significant changes in snail stressor genes, a critical intermediate host for several parasites. With the rising impacts of anthropogenic activity on the environment, there is an urgent need to reassess and adjust regulatory policies to minimize these threats. By studying the implications of pollution on host-parasite interactions, we can develop better strategies for disease control and improve the preservation of our ecosystem’s health.

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Downstream effects: Impact of antibiotic pollution on an aquatic host–parasite interaction

Cited by 3 publications

References 49 publications

Safety of Tetracyclines for Public Health and the Environment

Safety of Tetracyclines for Public Health and the Environment

Limited Impact of Schistosome Infection onBiomphalaria glabrataSnail Microbiomes

Contaminated freshwater as a Harbinger of tropical disease spread in Europe

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