Downstream Processing

Gottschalk, Uwe

doi:10.1002/9783527632909.ch8

Pharmaceutical Biotechnology 2012

DOI: 10.1002/9783527632909.ch8

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Downstream Processing

Uwe Gottschalk

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2014

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Natural products – learning chemistry from plants

Staniek

Bouwmeester

Fraser

et al. 2014

Biotechnology Journal

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Plant natural products (PNPs) are unique in that they represent a vast array of different structural features, ranging from relatively simple molecules to very complex ones. Given the fact that many plant secondary metabolites exhibit profound biological activity, they are frequently used as fragrances and flavors, medicines, as well as industrial chemicals. As the intricate structures of PNPs often cannot be mimicked by chemical synthesis, the original plant providers constitute the sole source for their industrial, large-scale production. However, sufficient supply is not guaranteed for all molecules of interest, making the development of alternative production systems a priority. Modern techniques, such as genome mining and thorough biochemical analysis, have helped us gain preliminary understanding of the enzymatic formation of the valuable ingredients in planta. Herein, we review recent advances in the application of biocatalytical processes, facilitating generation of complex PNPs through utilization of plant-derived specific enzymes and combinatorial biochemistry. We further evaluate the options of employing heterologous organisms harboring PNP biosynthetic pathways for the production of secondary metabolites of interest.

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Natural products – learning chemistry from plants

Staniek

Bouwmeester

Fraser

et al. 2014

Biotechnology Journal

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show abstract

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Downstream Processing

Cited by 1 publication

References 28 publications

Natural products – learning chemistry from plants

Natural products – learning chemistry from plants

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