2014
DOI: 10.7314/apjcp.2014.15.19.8377
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DOX-MTX-NPs Augment p53 mRNA Expression in OSCC Model in Rat: Effects of IV and Oral Routes

Abstract: Background: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy worldwide. Cancer development and progression require inactivation of tumor suppressor genes and activation of proto-oncogenes. The well recognized mechanism of action demonstrated for chemotherapeutic agents is induction of apoptosis via reactivation of p53. In this context, we evaluate the efficacy of IV and oral routes of our novel PH and temperature sensitive doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NP) in aff… Show more

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Cited by 15 publications
(15 citation statements)
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“…Despite efforts to improve overall outcomes, survival rates have not changed during the last 20 years [ 5 ]. Tongue cancer is the most common oral cavity neoplasm with an unfavorable prognosis and high metastatic potential [ 6 ]. Patients with premalignant lesions and early stage cancers have a high rate of survival, but the vast majority of Stages III and IV cases are fatal [ 7 ].…”
Section: Introductionmentioning
confidence: 99%
“…Despite efforts to improve overall outcomes, survival rates have not changed during the last 20 years [ 5 ]. Tongue cancer is the most common oral cavity neoplasm with an unfavorable prognosis and high metastatic potential [ 6 ]. Patients with premalignant lesions and early stage cancers have a high rate of survival, but the vast majority of Stages III and IV cases are fatal [ 7 ].…”
Section: Introductionmentioning
confidence: 99%
“…In our study, DPPH IC50 was obtained at 2.9µg/ml which indicates to the high antioxidant activity of Persian MOE compared to MO extract from Spain. In course of our interest on toxicological properties of different medicinal plants towards aggressive tumors (Abbasi et al, 2014a), in following study, we investigated the selective cytotoxicity of MO extract on a series of human cancers including ovarian cancer cells (SKOV3), breast adenocarcinoma cells (MCF-7), prostate adenocarcinoma cells (PC-3) and lung non small cancer cells (A549) by MTT assay. In course our interest on treatment of aggressive tumors; we specially selected these cancer cells because each displays a high propensity for metastasis in vivo.…”
Section: Resultsmentioning
confidence: 99%
“…These data imply that oral immunization with BFGF/PCEC NPs can be used as an effective anti‐angiogenesis vaccine in cancer immunotherapy (Long et al, ). Stimuli‐responsive cationic mesoporous silica NPs fabricated by the us was employed for co‐delivery of Doxorubicin/Methotrexate (DOX‐MTX) to cancer cells in vitro and in vivo (Abbasi, Khiavi et al, ). The dual temperature and pH responsive NPs were selectively accumulated at the tumor site and enabled simultaneous delivery of chemotherapeutics.…”
Section: Combination Of Nanotechnology With Vtas For Effective Cancermentioning
confidence: 99%
“…Multi‐targeting is an additional benefit of the nanostructures. The simultaneous targeting of several angiogenic markers for effective cancer therapy is feasible through the development of multi‐targeting nanosystems (Abbasi, Khiavi et al, ). Co‐conjugation of cRGD and anginex to liposomes create a dual‐targeting therapeutic and diagnostic tool which produces synergistic anti‐angiogenic potential through targeting two prominent angiogenesis‐related molecules, α v β 3 , and Galectin‐1, respectively (Kluza et al, ).…”
Section: Combination Of Nanotechnology With Vtas For Effective Cancermentioning
confidence: 99%