Doxapram and hypokalaemia in very preterm infants: Table 1

Abstract

This retrospective study underlines the high incidence of severe hypokalaemia in very preterm infants and an increased risk of severe hypokalaemia during doxapram treatment. We recommend potassium monitoring during any use of doxapram.

Doxapram Treatment for Apnea of Prematurity: A Systematic Review

“…Six studies reported on different short-term outcomes [20,21,22,24,25,26]. Yamazaki et al [26] showed that almost 80% of the infants treated with doxapram had a partial or complete cessation of apnea.…”

“…Two studies assessed neurodevelopmental sequelae at 12-18 months' corrected age [23,24]. Fischer et al [21 ]and Czaba-Hnizdo et al [20 ]had a low risk of bias , Yamazaki et al [26], Kumita et al [25] and Prins et al [22] had a high risk of bias, the risk of bias could not be assessed for the publications in abstract form only (fig. 3).…”

“…In addition, 130 studies were excluded for the reasons mentioned in figure 1. This left 32 studies for the final analyses, 4 RCTs [13,14,15,16], 1 prospective crossover study [17], 2 case-control studies [18,19], and 25 cohort, case series or case reports studies [20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44]. Four studies were only available in abstract form [19,23,24,38].…”

“…Five studies compared the outcomes of patients exposed to doxapram to those not exposed [20,21,23,24,26], 1 compared patients treated with high-dose doxapram (1.0-2.5 mg·kg -1 ·h -1 ) to patients treated with low-dose doxapram (0.2 mg·kg -1 ·h -1 ) [25], and 1 study described a cohort of doxapram-treated infants [22]. The studies included a total of 935 infants of variable GA (table 1).…”

“…Seven cohort studies were included [20,21,22,23,24,25,26], of which 2 were available in abstract form only [23,24]. Five studies compared the outcomes of patients exposed to doxapram to those not exposed [20,21,23,24,26], 1 compared patients treated with high-dose doxapram (1.0-2.5 mg·kg -1 ·h -1 ) to patients treated with low-dose doxapram (0.2 mg·kg -1 ·h -1 ) [25], and 1 study described a cohort of doxapram-treated infants [22].…”