Doxazosina en formulación de liberación retardada en la retención aguda de orina por hiperplasia benigna de próstata: Acción del incremento de dosis sobre el efecto rescate

Garín, J.A. Lorente; Sánchez, D. Cañís; Toro, Octavio Arango; Gali, O. Bielsa; Ángel, R. Cortadellas; Mas, A. Gelabert

doi:10.4321/s0210-48062004000100006

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…However, among the existing studies [4][5][6][7][8] , some fail to clearly define the persistence of severe symptoms, while others do not quantify postmicturition residue following the acute episode, or do not always determine posterior urinary flow. Fundamentally, however, none of these studies involves a follow-up period of over 1 year.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Doxazosin in the Treatment of Acute Urinary Retention due to Benign Prostate Hyperplasia

Prieto

Romero²,

López³

et al. 2008

Urol Int

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Objective: To evaluate the efficacy of modified-release doxazosin 4 mg in the treatment of patients with acute urinary retention (AUR) due to benign prostate gland hyperplasia (BPH). An evaluation is made of the number of patients recovering spontaneous micturition after catheter removal, micturition quality, and the number of patients suffering new AUR episodes or who require surgery in the 2 years following the first episode. Patients and Methods: A randomized, controlled study in males with AUR secondary to BPH. Two groups are formed, administering modified-release doxazosin 4 mg to patients born in even-numbered years, once a day in the morning. Those born in odd-numbered years receive no medication. The catheter is withdrawn 1 month later. Flowmetry is performed, with determination of ultrasonographic postmicturition retention at withdrawal, and after 6, 12 and 24 months. Results: Of the 65 patients included, 47 proved evaluable, and 46 complied with treatment (with exclusion of 1 case due to hypotension). Of the 22 patients treated with doxazosin, 15 (68.86%) presented AUR after 2 years, while 7 (31.2%) showed spontaneous micturition. Of the 24 patients treated with bladder catheterization in the absence of medication, 16 (66.6%) presented AUR after the same period of time, while 8 (33.3%) showed spontaneous micturition. There were no statistically significant differences between the treated and untreated subjects in terms of drug efficacy. Residual flow parameters are described in the population with spontaneous micturition in each stage of the study. Conclusion: In our series, treatment with the α-blocker doxazosin (4 mg, modified-release formulation), added to bladder catheterization, showed no increased efficacy in AUR treatment versus catheterization alone. Two years after the urinary retention episode, 31.2% of the patients treated with modified-release doxazosin 4 mg, and 33.3% of those with a bladder catheter only were seen to maintain spontaneous micturition.

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Section: Introductionmentioning

confidence: 99%

Efficacy of Doxazosin in the Treatment of Acute Urinary Retention due to Benign Prostate Hyperplasia

Prieto

Romero²,

López³

et al. 2008

Urol Int

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Acute urinary retention in men: the risks and outcomes with medical therapy

Hargreave

McNeill²

2005

Curr Urol Rep

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This paper is restricted to the discussion of the relatively modern disorder of sudden painful inability to urinate in older men. It was not a common medical problem until the 19th century when, in developed countries, male life expectancy increased to beyond 60 years; it remains an uncommon problem in those developing countries where male life expectancy remains low, particularly in some sub-Saharan African countries where male life expectancy is only 44.8 years.

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Doxazosina en formulación de liberación retardada en la retención aguda de orina por hiperplasia benigna de próstata: Acción del incremento de dosis sobre el efecto rescate

Cited by 2 publications

References 5 publications

Efficacy of Doxazosin in the Treatment of Acute Urinary Retention due to Benign Prostate Hyperplasia

Efficacy of Doxazosin in the Treatment of Acute Urinary Retention due to Benign Prostate Hyperplasia

Acute urinary retention in men: the risks and outcomes with medical therapy

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