Doxercalciferol Alleviates Bone Deteriorations and Cartilage
                    Degeneration in Aging Mice

Li, Jian; Li, Nan; Yan, Shuangtong; Liu, Minyan; Sun, Beicheng; Lu, Yanhui; Shao, Yi

doi:10.1055/a-0754-1956

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…In terms of cells, elimination of OCPs had no significant effect on age-related bone loss ( Kim et al, 2019 ) whereas macrophages promoted osteoclast production during aging ( Kanagasabapathy et al, 2020 ). Furthermore, doxercalferol (DOX) ( Li J. et al, 2020 ), Cnr1 and Cnr2 receptors ( Sophocleous et al, 2017 ), cadherin-13 ( Yang et al, 2020 ), GD3 Synthase ( Yo et al, 2019 ), and Kynurenine ( Refaey et al, 2017 ) all have a non-negligible role in aging osteoblasts.…”

Section: Behavior Changes Of Osteoclastmentioning

confidence: 99%

Recent Advances in Osteoclast Biological Behavior

Sun

Xie

et al. 2021

Front. Cell Dev. Biol.

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With the progress of the aging population, bone-related diseases such as osteoporosis and osteoarthritis have become urgent problems. Recent studies have demonstrated the importance of osteoclasts in bone homeostasis, implying these will be an important mediator in the treatment of bone-related diseases. Up to now, several reviews have been performed on part of osteoclast biological behaviors such as differentiation, function, or apoptosis. However, few reviews have shown the complete osteoclast biology and research advances in recent years. Therefore, in this review, we focus on the origin, differentiation, apoptosis, behavior changes and coupling signals with osteoblasts, providing a simple but comprehensive overview of osteoclasts for subsequent studies.

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Section: Behavior Changes Of Osteoclastmentioning

confidence: 99%

Recent Advances in Osteoclast Biological Behavior

Sun

Xie

et al. 2021

Front. Cell Dev. Biol.

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“…Osteoporosis, muscle weakness, secondary hyperparathyroidism, and calcium malabsorption are symptoms. 3,4 Vitamin D is crucial for boosting calcium absorption and healthy bone mineralization. Rickets in newborns and young children and osteomalacia in adults are both the results of severe vitamin D insufficiency.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Selective Reversed-phase High Performance Liquid Chromatography Method for the Quantification of 1 ALPHA -Hydroxy Vitamin D2 and its Impurities

Sheela¹,

Babu²,

Kumar³

2022

IJPQA

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A selective reversed-phase high-performance liquid chromatography (RP-HPLC) technique was developed for 1α-hydroxy vitamin D2 (Doxercalciferol) related substances analysis. The technique is proficient of eluting various impurities related to process and degradation. To separate both the vitamin D2 Analogs i.e., doxercalciferol and ergocalciferol. HPLC of Shimadzu, provided with autosampler, column oven, quaternary pump and UV detector, were used for development studies. The mobile phase used water and acetonitrile. The diluent used was methanol and detection was examined at wavelength 265 nm. The method is sensitive for doxercalciferol, ergocalciferol, impurity-A and impurity-B; the limit of detection (LoD), value is 0.01% and limit of quantitation (LoQ) value is 0.03%. Linearity of doxercalciferol and related impurities at various concentrations was performed and the obtained correlation coefficient for doxercalciferol is 0.995, ergocalciferol is 0.997, impurity-A is 0.990 and impurity-B is 0.993. The optimized method was validated and demonstrated that the technique is selective, precise, linear, sensitive and accurate. The method is simple, inexpensive and useful for routine testing of doxercalciferol API. In addition, the technique was effectively applied for the elution of both the vitamin D2 Analogs i.e., doxercalciferol and ergocalciferol. Further, the same method is applicable for the determination of assay for these two API’s and the same assay method was validated.

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The Role of PKM2 in Diabetic Microangiopathy

Tu¹,

Wang²,

Wei³

2022

DMSO

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Diabetic microangiopathy is among the most common complications affecting patients with diabetes, and includes both diabetic retinopathy (DR) and diabetic nephropathy (DKD). Diabetic microangiopathy remains a persistent threat to the health and quality of life of affected patients. Mechanistically, the severity of DR and DKD is tied to mitochondrial and glucose metabolism abnormalities, with the activation of the glycolytic enzyme pyruvate kinase M2 (PKM2) contributing to mitochondrial and glomerular dysfunction, abnormal renal hemodynamics, and retinopathy. PKM2 can activate inflammatory bodies in macrophages to promote the release of inflammatory mediators, and serves as a key regulator of inflammatory factors, chemokines and adhesion molecules. As such, there is sufficient evidence that PKM2 can be used as a biomarker for the diagnosis of diabetes and diabetic microangiopathy. Here, we survey the mechanisms whereby PKM2 contributes to diabetes-related microvascular diseases, associated regulatory roles, post-translational modifications, and the potential utility of PKM2 as a therapeutic target. Through this literature review, we have determined that PKM2 offers promise as both a diagnostic marker and therapeutic target with direct relevance to research pertaining to diabetic microangiopathy.

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Doxercalciferol Alleviates Bone Deteriorations and Cartilage Degeneration in Aging Mice

Cited by 3 publications

References 26 publications

Recent Advances in Osteoclast Biological Behavior

Recent Advances in Osteoclast Biological Behavior

Development and Validation of a Selective Reversed-phase High Performance Liquid Chromatography Method for the Quantification of 1 ALPHA -Hydroxy Vitamin D2 and its Impurities

The Role of PKM2 in Diabetic Microangiopathy

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