Doxorubicin/CpG self-assembled nanoparticles prodrug and dendritic cells co-laden hydrogel for cancer chemo-assisted immunotherapy

Yang, Afeng; Dong, Xia; Bai, Yun; Sheng, Shupei; Zhang, Yan; Liu, Tianjun; Zhu, Dunwan; Lv, Feng

doi:10.1016/j.cej.2021.129192

Cited by 31 publications

(14 citation statements)

References 43 publications

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“…Nanocarriers can be engineered to possess numerous features [ 16 ], such as sustainable release of antigen during a long period, preventing antigen degradation [ 17 , 18 ], and co-encapsulation of antigen and adjuvants [ 19 , 20 ]. Moreover, the nanoscale size and surface charge of nanocarriers contribute to antigen accumulation in lymph nodes (LNs) [ 21 , 22 ], resulting in achieving systemic transportation of antigen and eliciting protective immune responses [ 23 ]. Alternatively, nanocarriers are capable of cytosolic antigens delivery to achieve antigen cross-presentation [ 24 ], which can elicit potent T cell responses to realize disease prevention and treatment [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Splenic-targeting biomimetic nanovaccine for elevating protective immunity against virus infection

et al. 2022

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Background The prevalence of viral infectious diseases has become a serious threat to public safety, economic and social development. Vaccines have been served as the most effective platform to prevent virus transmission via the activation of host immune responses, while the low immunogenicity or safety, the high cost of production, storage, transport limit their effective clinical application. Therefore, there is a need to develop a promising strategy to improve the immunogenicity and safety of vaccines. Methods We developed a splenic-targeting biomimetic nanovaccine (NV) that can boost protective humoral and cellular immunity against african swine fever virus (ASFV) infection. The universal PLGA nanoparticles (CMR-PLGA/p54 NPs) coated with mannose and CpG (TLR9 agonist) co-modified red blood cell (RBC) membrane were prepared, which comprised a viral antigen (p54) and can be served as a versatile nanovaccine for elevating protective immunity. Results CMR-PLGA/p54 NVs could be effectively uptaken by BMDC and promoted BMDC maturation in vitro. After subcutaneous immunization, antigen could be effectively delivered to the splenic dendritic cells (DCs) due to the splenic homing ability of RBC and DC targeting capacity of mannose, which promoted antigen presentation and DCs maturation, and further elicited higher levels of cytokines secretion and specific IgG titers, CD4+ and CD8+ T cells activation and B maturation. Moreover, NVs demonstrated notable safety during the immunization period. Conclusions This study demonstrates the high potential of CMR-PLGA NPs as vaccine delivery carriers to promote humoral and cellular immune responses, and it provides a promising strategy to develop safe and effective vaccines against viral infectious diseases.

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Section: Introductionmentioning

confidence: 99%

Splenic-targeting biomimetic nanovaccine for elevating protective immunity against virus infection

et al. 2022

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“…Clinical treatment-activated immunogenic cell death (ICD) can reinforce tumor immunotherapy by stimulating the autoimmune system through secreting associated signals. At present, therapeutic means like chemotherapy and phototherapy can induce ICD, with cytotoxic •OH and 1 O 2 involved in regulation ICD 36 - 38 . In consequence, increased intracellular ROS levels are highly proposed to amplify ICD and PDT could effectively arouse immunogenicity during treatment 39 , 40 .…”

Section: Introductionmentioning

confidence: 99%

Polyamino acid calcified nanohybrids induce immunogenic cell death for augmented chemotherapy and chemo-photodynamic synergistic therapy

Qiu¹,

Liang²,

Gao³

et al. 2021

Theranostics

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Background: Monotherapy for cancer treatment is limited by unstable efficacy and uncontrollable toxic side effects, while the multifunctional nanoplatform with complex preparation process cannot avoid the potential toxicity of each functional component. Methods: We exploited tumor-specific activated polyamino acid calcified nanoparticles (CHC NPs) as new-type oxidative stress amplification of anticancer drugs via building a safe and biodegradable multifunctional nanoplatform. Giving priority to chemotherapy, and synergizing chemodynamic therapy (CDT) with photodynamic therapy (PDT), this strategy was to achieve enhanced chemotherapy, simultaneously inducing immunogenic cell death and inhibiting tumor cell invasion. Results: Based on amorphous calcium carbonate, pH-responsive nanocarrier was prepared with classical chemotherapeutic drug 10-hydroxycamplothecin (HCPT) and photosensitizer Chlorin e6 (Ce6) to realize multifunctional nanotheranostics. Conclusion: Inventive calcified nanohybrids, where topoisomerase inhibited by HCPT to prevent DNA synthesis, the generation of •OH induced via Fenton reaction, along with a large amount of 1 O 2 produced by Ce6, might be a promising strategy for anti-tumor combination therapy in clinical translation.

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“…The porous and hydrophilic 3D networks of macroscale biomaterials are promising for cellular therapeutics. Afeng Yang et al designed α-cyclodextrin and PEG co-crosslinked hydrogels for DC cancer vaccines [ 111 ]. The co-laden DOX/CpG nanoparticles as prodrugs offered DOX-stimulated tumor antigens and immunoadjuvants rising the antigen presentation levels of DCs.…”

Section: Modern Immunotherapeutic Strategies Based On 3d Macroscale B...mentioning

confidence: 99%

Three-dimensional (3D) scaffolds as powerful weapons for tumor immunotherapy

Han

2022

Bioactive Materials

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Doxorubicin/CpG self-assembled nanoparticles prodrug and dendritic cells co-laden hydrogel for cancer chemo-assisted immunotherapy

Cited by 31 publications

References 43 publications

Splenic-targeting biomimetic nanovaccine for elevating protective immunity against virus infection

Splenic-targeting biomimetic nanovaccine for elevating protective immunity against virus infection

Polyamino acid calcified nanohybrids induce immunogenic cell death for augmented chemotherapy and chemo-photodynamic synergistic therapy

Three-dimensional (3D) scaffolds as powerful weapons for tumor immunotherapy

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