Doxorubicin-dependent skeletal muscle atrophy: exercise and mitochondrial dysfunction

Abstract

Doxorubicin (DOX) is a type of chemotherapy with harmful side effects due to its accumulation in various tissues. DOX is widely known for having a significant effect on skeletal muscle atrophy. The most significant of these side effects is DOX-induced mitochondrial dysfunction in skeletal muscle atrophy. Exercise is a treatment approach that serves to maintain muscle homeostasis by decreasing or eliminating these effects. The goal of this review article is to give current knowledge on the causes of DOX-induced skeletal muscle atrophy, the basic processes involved in mitochondrial dysfunction caused by DOX, and the effects of exercise on DOX-induced skeletal muscle atrophy.