Doxorubicin Encapsulated Nanocarriers for Targeted Delivery to Estrogen Responsive Breast Cancer

Rai, Shivani; Paliwal, Rishi; Vyas, Suresh P.

doi:10.1166/jbn.2011.1231

Cited by 32 publications

(14 citation statements)

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“…In particular, dendrimers covalently conjugated targeting molecules as well as drug molecules will greatly reduce negative effects of medications on healthy cells. [56][57][58][59][60] Dendrimers have been widely explored to encapsulate antiretroviral bioactive materials in order to enhance efficacy of antiretroviral drugs. [61][62][63][64][65][66][67][68] Targeting dendrimers make great contribution to promote tumor cell uptake and prolong drug release time in cancer cells.…”

Section: Drug Carriersmentioning

confidence: 99%

Advances in Applications of Dendritic Compounds

Ma²,

Deng³

et al. 2013

j. nanosci. nanotech.

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Dendritic compounds (so-called dendrimers) with nano-scale represent unique symmetric and spherical structures. They are usually prepared through two fundamental methods based on molecular level which involved the convergent method and divergent method, although the synthetic methods have a tendency towards the diversity and functionalization. The outershell of dendrimers with rich peripheral reactive sites are easily modified by small functional molecules. Moreover, the higher generation dendrimers also possess more exposed functional groups on the surface prior to the previous one and they are much easily customized for much more applications. Consequently, based on previous researches, this review summarized wide applications of dendritic compounds in many fields which were investigated in detail, including gene vector, drug carrier, catalysis, sensor industry, photoelectric material, etc. Dendrimers provide promising tools for the cellular delivery of molecular cargos ranging in size from small molecules and peptides to proteins and DNA. More importantly, it is necessary to explore new synthetic methods and undiscovered applications of new dendrimers.

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Section: Drug Carriersmentioning

confidence: 99%

Advances in Applications of Dendritic Compounds

Ma²,

Deng³

et al. 2013

j. nanosci. nanotech.

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“…Therefore, estrogen could potentially serve as a ligand conjugated to a nanomaterial for targeting estrogen receptors present on breast cancer. However, few studies to date have explored the conjugation of estrogen ligands to multifunctional nanoparticles [16]. Breast cancer magnetic resonance imaging (MRI) has been shown to have high sensitivity in detecting small breast tumors, however, the specificity is relatively low due to false positive signals [17].…”

Section: Targeting Of Nanoparticles For Delivery To Metastatic Breastmentioning

confidence: 99%

Nanoparticle delivery for metastatic breast cancer

Grobmyer¹,

Zhou²,

Gutwein³

et al. 2012

Maturitas

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Breast cancer represents a major ongoing public health problem as the most common non-cutaneous malignancy among U.S. women. While significant progress has been made in improving loco-regional treatments for breast cancer, relatively little progress has been made in diagnosing and treating patients with metastatic breast cancer. At present there are limited curative options for patients with breast cancer metastatic beyond regional nodes. Emerging nanotechnologies promise new approaches to early detection and treatment of metastatic breast cancer. Fulfilling the promise of nanotechnologies for patients with metastatic breast cancer will require delivery of nanomaterials to sites of metastatic disease. Future translational approaches will rely on an ever increasing understanding of the biology of breast cancer subtypes and their metastases. These important concepts will be highlighted and elucidated in this manuscript.

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“…25 and nanotubes. In vivo cancer treatment studies with carbon nanotubes loading Dox by systemic administration achieved longer blood circulation half-life and higher tumor uptake using branched PEG functionalized SWNTs, and eventually better therapeutic benefits.…”

Section: In Vivo Anti-tumor Activity Of Tpgs-swnts-doxmentioning

confidence: 99%

Efficacy and Biodistribution of Tocopheryl Polyethylene Glycol Succinate Noncovalent Functionalized Single Walled Nanotubes Loading Doxorubicin in Sarcoma Bearing Mouse Model

Wang¹,

Xu²,

Liu³

et al. 2012

j biomed nanotechnol

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The aim of this study is to develop the noncovalent functionalized single walled nanotubes loading doxorubicin. A tocopheryl polyethylene glycol succinate (TPGS) noncovalent modification of single walled carbon nanotubes (SWNTs) loading antitumor agent doxorubicin (Dox) via the physical absorption was developed. Dox was successfully loaded onto the surface of carbon nanotubes (loading amount was 168.7 g/ml), which was confirmed by UV-vis-NIR absorbance spectra and dynamic light scattering assay. ICR mice bearing mouse sarcoma tumor were subjected to intratumoral injection of TPGS-SWNTs-Dox. Based on the in vivo antitumor activities of the locally injected the formulation into the tumor bearing mice, it was shown that there was modest (up to 50.2%) delay of tumor growth compared with the groups receiving no treatment, which was better than free dox (up to 40.2%). The biodistribution studies demonstrated that there were the longest retention time in tumor, the highest tumor accumulation, as well as less accumulation in other solid tissues, especially in heart, when tumor bearing mice were administered with TPGS-SWNTs-Dox. It may be attributed to the enhanced permeability and retention (EPR) effect of TPGS-SWNTs-Dox. The histopathological findings revealed that the new carbon nanomaterials were a safe vehicle for topical drug delivery systems. These results suggested that the noncovalent modification of carbon nanotubes by TPGS for anticancer agents may be a promising strategy for cancer treatment.

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Doxorubicin Encapsulated Nanocarriers for Targeted Delivery to Estrogen Responsive Breast Cancer

Cited by 32 publications

References 0 publications

Advances in Applications of Dendritic Compounds

Advances in Applications of Dendritic Compounds

Nanoparticle delivery for metastatic breast cancer

Efficacy and Biodistribution of Tocopheryl Polyethylene Glycol Succinate Noncovalent Functionalized Single Walled Nanotubes Loading Doxorubicin in Sarcoma Bearing Mouse Model

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