Doxorubicin-Induced Cardiotoxicity

Zhu, Hongxin

doi:10.5772/intechopen.78791

Cited by 6 publications

(4 citation statements)

References 97 publications

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“…Oxidative stress, which is mainly caused by the overaccumulation of ROS, is one of the major contributors to CVDs [4,5,26] . DOX has been reported to impair antioxidant enzyme activity, increase ROS levels, and ultimately cause damage to cardiomyocytes [27,28] . Therefore, the cellular ROS production in DOX‐treated H9c2 cells was examined by staining the cells with 2′,7′‐dichlorodihydrofluorescein diacetate (DFCH‐DA).…”

Section: Resultsmentioning

confidence: 99%

“…[4,5,26] DOX has been reported to impair antioxidant enzyme activity, increase ROS levels, and ultimately cause damage to cardiomyocytes. [27,28] Therefore, the cellular ROS production in DOX-treated H9c2 cells was examined by staining the cells with 2',7'-dichlorodihydrofluorescein diacetate (DFCH-DA). The results showed a higher green fluorescence intensity in DOX-treated H9c2 cells compared to the control group, indicating that DOXinduced ROS overaccumulation (Figure 7B -C).…”

Section: Cardioprotective Effects Of 4e By Inhibiting Oxidative Stres...mentioning

confidence: 99%

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Discovery of New D‐Ring Modified Isosteviol Derivatives as Potent Cardioprotective Agents against Oxidative Stress‐Trigged Damage

Zhao

Chen

et al. 2023

Chemistry & Biodiversity

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Cardiovascular diseases (CVDs) are a major global health concern, and oxidative stress is known to play a central role in their pathogenesis. The identification of new agents capable of inhibiting oxidative stress presents a promising strategy for preventing and treating CVDs. Natural products and their derivatives offer a valuable source for drug discovery, and isosteviol, a readily available natural product, is known to exhibit cardioprotective effects. In this study, 22 new D-ring modified isosteviol derivatives were synthesized and evaluated for their cardioprotective effect in vivo using the zebrafish cardiomyopathy model. The findings revealed that derivative 4e exhibited the most potent cardioprotective effect, surpassing its parent compound isosteviol and the positive drug levosimendan. At 1 μM, derivative 4e significantly protected the cardiomyocytes from injury, while at 10 μM it effectively maintained normal heart phenotypes, preventing cardiac dysfunction in zebrafish. Further investigation demonstrated that 4e protected cardiomyocytes from oxidative stress-induced damage by inhibiting reactive oxygen species overaccumulation, activating superoxide dismutase 2 expression, and enhancing the endogenous antioxidant defense system. These results suggest that isosteviol derivatives, particularly 4e, have the potential to serve as a novel class of cardioprotective agents for the prevention and treatment of CVDs.

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Section: Resultsmentioning

confidence: 99%

Section: Cardioprotective Effects Of 4e By Inhibiting Oxidative Stres...mentioning

confidence: 99%

Discovery of New D‐Ring Modified Isosteviol Derivatives as Potent Cardioprotective Agents against Oxidative Stress‐Trigged Damage

Zhao

Chen

et al. 2023

Chemistry & Biodiversity

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“…FMT obtained a similar effect implemented a day after doxorubicin administration. Then attenuation of doxorubicin-induced dysbiosis and heart function improvement were assessed by left ventricular ejection fraction, and loss of cardiac fibrosis was observed [56]. This must be evaluated in clinical practice, as it raises the possibility of dealing with anthracycline-induced cardiotoxicity.…”

Section: Hodgkin Lymphomamentioning

confidence: 99%

Influence of gut microbiota on efficacy and adverse effects of treatment of lymphoproliferative disorders

2022

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Gut microbiota has aroused great interest because of its influence on the human body's homeostasis. In addition, multiple reports have indicated its role in the pathogenesis of various diseases. Interestingly, gut microbiota can affect hematological disorders by participating in lymphomagenesis. Patients with lymphoproliferative disorders undergo many procedures that alter their unique microbiota composition and lead to dysbiosis. However, this can have a biased effect as many studies have highlighted gut microbiota's activity in chemotherapy efficacy, for instance by either enhancing the anti-malignant effects of cyclophosphamide or by diminishing the activity of doxorubicin or cladribine. This review aimed to summarize gut microbiota's influence on chemotherapy's outcomes on treatment-related side effects in lymphoproliferative disorders, antimicrobial regimens, and possible gut microbiota modifications to enhance treatment outcomes.

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“…Many heart diseases are associated with excess production of Reactive Oxygen Species (ROS) [57] . If the balance between ROS production and the antioxidant system is disrupted in ROS production, oxidative stress occurs, which triggers several deleterious events, including DNA damage [57][58][59] . Also, insufficient antioxidant defense systems in the heart make it vulnerable to ROSmediated cellular damage [60,61] .…”

Section: Table 3: Effects Of Citalopram Administration On Gsh and Mda...mentioning

confidence: 99%

Citalopram Induced Cardiotoxicity in Rats at Repeated Doses

Ozlem¹,

Volkan²,

Merve³

et al. 2022

IJPS

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Although the correlation between citalopram and cardiovascular pathologies was realized via case studies, there is no experimental study that was performed independently of other risk factors related to cardiotoxicity. In the study reported here, we aimed to identify the cardiotoxic effects of citalopram by evaluating serum cardiac biomarkers, such as serum aspartate transaminase, creatine kinase-myoglobin binding, lactate dehydrogenase and troponin-T levels as well as electrocardiogram parameters, deoxyribonucleic acid damage in cardiomyocytes and histological findings of heart tissue in rats that were administered oral doses of 5, 10, or 20 mg/kg of citalopram for 28 d. Additionally, to investigate possible mechanisms underlying cardiotoxicity, glutathione and malondialdehyde levels in cardiac tissue were determined to evaluate oxidative stress. According to our results, heart rates were increased, PR intervals were prolonged, and T wave amplitudes were significantly decreased in the 20 mg/kg citalopram-administered groups when compared with the control group. Additionally, serum aspartate transaminase, lactate dehydrogenase and troponin-T levels were significantly increased in the 10 and 20 mg/kg citalopram-administered group compared to the control group. Significant deoxyribonucleic acid damages were observed in the 10 and 20 mg/kg citalopramadministered groups. Histopathological investigations revealed degenerative changes in the 10 and 20 mg/ kg citalopram-administered groups. In heart tissues, glutathione levels were decreased in the 10 and 20 mg/kg citalopram-administered groups significantly when compared with the control group. These findings indicated the relationship between high-dose and subtherapeutic-dose citalopram administration and cardiac morphological, biochemical and functional toxic effects.

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Doxorubicin-Induced Cardiotoxicity

Cited by 6 publications

References 97 publications

Discovery of New D‐Ring Modified Isosteviol Derivatives as Potent Cardioprotective Agents against Oxidative Stress‐Trigged Damage

Discovery of New D‐Ring Modified Isosteviol Derivatives as Potent Cardioprotective Agents against Oxidative Stress‐Trigged Damage

Influence of gut microbiota on efficacy and adverse effects of treatment of lymphoproliferative disorders

Citalopram Induced Cardiotoxicity in Rats at Repeated Doses

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