Doxorubicin-loaded environmentally friendly carbon dots as a novel drug delivery system for nucleus targeted cancer therapy

Yuan, Yixiao; Guo, Boling; Hao, Liang; Liu, Na; Lin, Yunfeng; Guo, Wushuang; Li, Xiaoguang; Gu, Bohong

doi:10.1016/j.colsurfb.2017.07.030

Cited by 154 publications

(93 citation statements)

References 51 publications

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“…The CDs showed the average ZP value of À7.54 mV (Figure 2(c)), which is characteristic of CDs. This observed result can be representing the presence of carboxyl and oxygen functional groups on the surface of CDs [43]. Figure 3(a) displays the UV-vis absorption and PL spectra of the CDs-PEG.…”

Section: Characterization Of Cds-pegmentioning

confidence: 83%

Microwave-assisted and one-step synthesis of PEG passivated fluorescent carbon dots from gelatin as an efficient nanocarrier for methotrexate delivery

Arsalani

Nezhad‐Mokhtari

Jabbari

2019

Artificial Cells, Nanomedicine, and Biotechnology

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A green and simple process for preparing the polyethylene glycol passivated fluorescent carbon dots (CDs-PEG) have been studied by a microwave pyrolysis method, using gelatin and PEG as starting materials. This method is very effective for development of carbon-based quantum dots from gelatin with high quantum yield (QY). The synthesized CDs-PEG were found to emit blue photoluminescence (PL) with a maximum QY of 34%. At the following research, we investigated the effect of the presence of PEG on PL intensity, and the result showed that CDs-PEG becomes stronger PL properties than pure CDs from gelatin. The synthesized CDs-PEG were characterized by FTIR, TEM, UV-vis, PL, zeta potential and XRD analyses. The anticancer performance of developed CDs-PEG was evaluated by in vitro tests such as MTT assay and fluorescence microscopy analyses. The examination of CDs-PEG as an anticancer drug nanocarrier for methotrexate (MTX) illustrated a better antitumor efficacy than free MTX due to its enhanced nuclear delivery in vitro, which resulting in highly effective tumour growth inhibition and improving targeted cancer therapy in clinical medicine.

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Section: Characterization Of Cds-pegmentioning

confidence: 83%

Microwave-assisted and one-step synthesis of PEG passivated fluorescent carbon dots from gelatin as an efficient nanocarrier for methotrexate delivery

Arsalani

Nezhad‐Mokhtari

Jabbari

2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…Owing to these properties, carbon dots (CDs) have tremendous potential to be used in a number of applications such as cell imaging and sensing [4][5][6]. Fluorescence carbon nanoparticle (CNP) shows high potential in biological labeling, bio-imaging and other different optoelectronic device application [7,8], targeted drug delivery [9,10] in cancer theranostics [11,12], and drug delivery [13]. In addition to this, they find multiple applications in analytical chemistry [14].…”

Section: Introductionmentioning

confidence: 99%

Blue light-emitting carbon dots (CDs) from a milk protein and their interaction with Spinacia oleracea leaf cells

Bajpai

D'Souza²,

Suhail

2019

Int Nano Lett

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The milk protein casein (Cas) has been employed as carbon resource material to synthesize nitrogen-doped carbon dots (N-CDs) via microwave exposure. The dots, when exposed to UV light, produced blue fluorescence. The N-CDs were characterized by ultra violet (UV) spectroscopy, Fourier transformation infrared spectroscopy, X-ray diffraction (XRD), dynamic light scattering analysis, fluorescent microscopy (FM), and transmission electron microscopy (TEM). The XRD analysis revealed a broad peak at 2θ = 20°, thus indicating the turbostratic carbon phase. TEM analysis and particle size distribution curve revealed that nearly, 85% of the particles had diameter below 10 nm and the particles had spherical geometry. The HRTEM analysis revealed that carbon dots exhibited lattice fringes with a d-spacing of 0.21 nm, corresponding to the (100) plane lattice of graphite. The fluorescence spectral studies indicated a red shift in the emission peak from 420 to 450 nm as the excitation wavelength increased from 300 to 340 nm. The zeta potential of particles was found to be -11.3 mV. Finally, impregnation of N-CDs was studied in Spinacia oleracea leaf. It was observed that as the concentration of N-CDs' solution increased, percent insertion (PI) also increased, but the time required for maximal insertion decreased with increasing concentrations of N-CDs in the feed solutions. In the carbon dots' solution with a concentration of 200 ppm, maximum percent insertion (MPI) was obtained after 80 min. However, with the increasing concentration of N-CDs in the feed solutions, time of getting MPI reduced, i.e., in 600 ppm, it was 30 min, and in 800 ppm, it was 10 min.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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“…22 The medium was refreshed every 2 or 3 days. ACC-2 cells were cultured in RPMI 1640 medium including 10% FBS and 1% penicillin-streptomycin in a 37℃ humidified incubator with 5% CO 2 .…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

The endocytic pathways of carbon dots in human adenoid cystic carcinoma cells

et al. 2019

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Objectives: This study aimed at investigating cellular uptake pathways of carbon dots (CDs) in human adenoid cystic carcinoma cell line ACC-2. Materials and methods:We synthesized CDs using a hydrothermal method with citric acid and polyethylenimine (PEI, Mw = 25 000). The CDs incubated with the ACC-2 cells showed their bioimaging capabilities using a confocal microscopy test. Flow cytometry was used to analyse cellular uptake pathways of CDs in ACC-2 cells.Results: Our findings indicated that CDs possessed good biocompatibility in ACC-2 cells. CDs were endocytosed mainly via micropinocytosis and energy-dependent pathways. Conclusions:In general, these findings suggested that CDs had excellent biomedical imaging properties for ACC-2 cells and there was a potential opportunity to develop biomedical applications.

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Doxorubicin-loaded environmentally friendly carbon dots as a novel drug delivery system for nucleus targeted cancer therapy

Cited by 154 publications

References 51 publications

Microwave-assisted and one-step synthesis of PEG passivated fluorescent carbon dots from gelatin as an efficient nanocarrier for methotrexate delivery

Microwave-assisted and one-step synthesis of PEG passivated fluorescent carbon dots from gelatin as an efficient nanocarrier for methotrexate delivery

Blue light-emitting carbon dots (CDs) from a milk protein and their interaction with Spinacia oleracea leaf cells

The endocytic pathways of carbon dots in human adenoid cystic carcinoma cells

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