Doxorubicin-loaded folate-mediated pH-responsive micelle based on Bletilla striata polysaccharide: Release mechanism, cellular uptake mechanism, distribution, pharmacokinetics, and antitumor effects

Zhang, Guangyuan; Huang, Long; Wu, Ji; Liu, Yuran; Guan, Qing

doi:10.1016/j.ijbiomac.2020.07.123

Cited by 36 publications

(10 citation statements)

References 62 publications

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“…This was consistent with the results reported previously. 57 This mechanism enabled Fe-PDA-EPI@FA-RBCm NPs to enter lysosomes, which further enabled Fe 3+ to be rapidly and massively released for efficient lipid peroxidation.…”

Section: Resultsmentioning

confidence: 99%

Enhanced photothermal-ferroptosis effects based on RBCm-coated PDA nanoparticles for effective cancer therapy

Yan

et al. 2023

J. Mater. Chem. B

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Section: Resultsmentioning

confidence: 99%

Enhanced photothermal-ferroptosis effects based on RBCm-coated PDA nanoparticles for effective cancer therapy

Yan

et al. 2023

J. Mater. Chem. B

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“…Furthermore, Chinese researchers also evaluated the germplasm resources of B. formosana in Yunnan Province, determined the total phenol content of B. striata in Northwest Hubei Province, and determined the polysaccharide content of B. striata from different areas in Anhui and Guizhou Provinces. To evaluate the quality differences, fuzzy matter-element analysis and gray pattern recognition analysis were used to analyze the contents of extract, polysaccharide, militarine and total phenol of 30 populations of B. striata from main producing areas in Guizhou Province [7]. In this study, 33 Bletilla populations (including 28 B. striata populations and 5 B. ochracea populations), which covered their major distribution areas in China, were used for resource quality evaluation.…”

Section: Discussionmentioning

confidence: 99%

“…B. ochracea and B. formosana are also used as local medications or substitutes [3]. Currently, Bletilla research is focus mainly on chemical components, pharmacological activities and reproductive techniques, while there has been little systemic evaluation of the germplasm quality of Bletilla plants in China [4][5][6][7][8][9]. B. striata polysaccharide (BSP) is rich in the dried pseudobulb with content of 20-50% [10,11].…”

Section: Introductionmentioning

confidence: 99%

Phenotype - Chemotype Correlation of the Herb Bletilla Rchb. f. Based on a Comprehensive Evaluation of Thirty- Three Geographic Populations

Huang

Fang

Zhou

et al. 2021

Preprint

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Background The Bletilla genus of Orchidaceae includes plants with great economic value, among which B. striata is the main traditional medicinal plant, and its pseudobulb, known as BaiJi, was first recorded in Shennong's Classic of Materia Medica. However, there has been little systemic evaluation of the germplasm quality of Bletilla plants in China. In order to comprehensive evaluate the Bletilla resources in China and screen out the candidate phenotypic traits determining yield and/or quality of Bletilla, the variation of phenotypic indicators (pseudobulb, leaf, stem, inflorescence, flower) and active ingredients contents (polysaccharide, total phenolics and militarine) in different populations of B. striata and B. ochracea were investigated through 4 years' common-garden experiment. Results There were abundant phenotypic variations and significant differences among different populations in the morphological phenotypes, pseudobulb weight and main active ingredient contents. Five populations, including HNSZ, AHBZ, HBLT, HBSN and JSNJ, showed good prospects for industrial development, presenting higher quality in terms of yield and main active ingredient content. Pseudobulb yield, polysaccharide and total phenol content are positively correlated with phenotypic traits. Militarine content is negatively correlated with almost all indexes. Plant height, leaf width and stem diameter may be important indicators of potential excellent germplasms. Conclusions Bletilla is not strictly geoauthentic medicinal plants. B. ochracea could be accepted as an alternative resource to B. striata. The best harvest period of Bletilla is the third year after cultivation. Plant height, leaf width and stem diameter may be important indicators of potential excellent germplasms. These results provide important information required for the efficient screening and utilization of Bletilla germplasm resources.

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“…The pH-responsive release effect of FA-BSP-SA micelles was observed, leading to increased release of Dox in acidic condition. The in vivo study conducted in mice showed a decrease of tumour weight and volume [77]. The new redox-sensitive polymeric micelles targeted with folic acid (FHSV-folic acidhyaluronic acid SS-vitamin E succinate) for paclitaxel delivery (Ptx/FHSV) were designed by Yang et al The nanoparticles characterize enhanced cell internalization caused by folic acid and redox-sensitivity leading to rapid drug release in presence of high concentration of glutathione (GSH).…”

Section: Drug Delivery Application Single-drug Deliverymentioning

confidence: 99%

Single- versus Dual-Targeted Nanoparticles with Folic Acid and Biotin for Anticancer Drug Delivery

et al. 2021

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Cancer is one of the major causes of death worldwide and its treatment remains very challenging. The effectiveness of cancer therapy significantly depends upon tumour-specific delivery of the drug. Nanoparticle drug delivery systems have been developed to avoid the side effects of the conventional chemotherapy. However, according to the most recent recommendations, future nanomedicine should be focused mainly on active targeting of nanocarriers based on ligand-receptor recognition, which may show better efficacy than passive targeting in human cancer therapy. Nevertheless, the efficacy of single-ligand nanomedicines is still limited due to the complexity of the tumour microenvironment. Thus, the NPs are improved toward an additional functionality, e.g., pH-sensitivity (advanced single-targeted NPs). Moreover, dual-targeted nanoparticles which contain two different types of targeting agents on the same drug delivery system are developed. The advanced single-targeted NPs and dual-targeted nanocarriers present superior properties related to cell selectivity, cellular uptake and cytotoxicity toward cancer cells than conventional drug, non-targeted systems and single-targeted systems without additional functionality. Folic acid and biotin are used as targeting ligands for cancer chemotherapy, since they are available, inexpensive, nontoxic, nonimmunogenic and easy to modify. These ligands are used in both, single- and dual-targeted systems although the latter are still a novel approach. This review presents the recent achievements in the development of single- or dual-targeted nanoparticles for anticancer drug delivery.

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Doxorubicin-loaded folate-mediated pH-responsive micelle based on Bletilla striata polysaccharide: Release mechanism, cellular uptake mechanism, distribution, pharmacokinetics, and antitumor effects

Cited by 36 publications

References 62 publications

Enhanced photothermal-ferroptosis effects based on RBCm-coated PDA nanoparticles for effective cancer therapy

Enhanced photothermal-ferroptosis effects based on RBCm-coated PDA nanoparticles for effective cancer therapy

Phenotype - Chemotype Correlation of the Herb Bletilla Rchb. f. Based on a Comprehensive Evaluation of Thirty- Three Geographic Populations

Single- versus Dual-Targeted Nanoparticles with Folic Acid and Biotin for Anticancer Drug Delivery

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