Doxorubicin Loaded Green Synthesized Nanoceria Decorated Functionalized Graphene Nanocomposite for Cancer-Specific Drug Release

Palai, Prakash Kumar; Mondal, Aparna; Chakraborti, Chandra Kanti; Banerjee, Indranil; Pal, Kunal; Vuppaladadium, Shanmuga Sharan Rathnam

doi:10.1007/s10876-019-01599-4

Cited by 17 publications

(8 citation statements)

References 66 publications

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Section: Business Criteria For the Development Of Drug Carriersmentioning

confidence: 99%

“…For example, Palai et al described the synthesis of a decorated graphene nanocomposite, where the aqueous neem leaf extract was used to reduce graphene oxide, while the synthetic procedure was modified to reduce the number of toxic gases and impurities generated. 207 One of the latest examples of the use of eco-friendly reagents was delivered by Uthappa et al, who described the green synthesis of natural diatoms modified with polydopamine as a drug delivery system, in which additionally the synthesis time was reduced and no toxic reagents and solvents were used. 87 Furthermore, Hasan et al described the eco-friendly synthesis of silver nanoparticles in which the reduction process by chemical compounds has been replaced by a reduction by a biopolymer (dextrin).…”

Section: Primary Outcome Measuresmentioning

confidence: 99%

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Current Trends and Challenges in Pharmacoeconomic Aspects of Nanocarriers as Drug Delivery Systems for Cancer Treatment

Milewska¹,

Niemirowicz-Laskowska²,

Siemiaszko³

et al. 2021

IJN

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Nanotherapy is a part of nanomedicine that involves nanoparticles as carriers to deliver drugs to target locations. This novel targeting approach has been found to resolve various problems, especially those associated with cancer treatment. In nanotherapy, the carrier plays a crucial role in handling many of the existing challenges, including drug protection before early-stage degradations of active substances, allowing them to reach targeted cells and overcome cell resistance mechanisms. The present review comprises the following sections: the first part presents the introduction of pharmacoeconomics as a branch of healthcare economics, the second part covers various beneficial aspects of the use of nanocarriers for in vitro, in vivo, and pre- and clinical studies, as well as discussion on drug resistance problem and present solutions to overcome it. In the third part, progress in drug manufacturing and optimization of the process of nanoparticle synthesis were discussed. Finally, pharmacokinetic and toxicological properties of nanoformulations due to up-to-date studies were summarized. In this review, the most recent developments in the field of nanotechnology’s economic impact, particularly beneficial applications in medicine were presented. Primarily focus on cancer treatment, but also discussion on other fields of application, which are strongly associated with cancer epidemiology and treatment, was made. In addition, the current limitations of nanomedicine and its huge potential to improve and develop the health care system were presented.

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Section: Business Criteria For the Development Of Drug Carriersmentioning

confidence: 99%

Section: Primary Outcome Measuresmentioning

confidence: 99%

Current Trends and Challenges in Pharmacoeconomic Aspects of Nanocarriers as Drug Delivery Systems for Cancer Treatment

Milewska¹,

Niemirowicz-Laskowska²,

Siemiaszko³

et al. 2021

IJN

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“…Zeta potential is an important factor to evaluate the storage stability of colloidal dispersion. The higher value of the zeta potential increases the particles’ stability. , The zeta potential analysis shows that the Au–Ni nanomotors and PSS/Au–Ni nanomotors have a negative charge (−57 and −49.1 mV), whereas DOX/PSS/Au–Ni nanomotors have a positive charge (2.03 mV), as illustrated in Figure C. The positive zeta potential result of DOX/PSS/Au–Ni nanomotors presents the interaction between the negatively charged sulfonate group of the PSS and the positively charged amine group of DOX.…”

Section: Resultsmentioning

confidence: 92%

Gold–Nickel Nanowires as Nanomotors for Cancer Marker Biodetection and Chemotherapeutic Drug Delivery

Karaca

Kuralay

Uygun

et al. 2021

ACS Appl. Nano Mater.

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Future biomedical applications of nanomachines require elimination of fuel requirements since most of the fuels have potential toxic effects. Herein, we report fuel-free magnetically powered gold–nickel (Au–Ni) nanowires as nanomotors for multipurpose biomedical applications. Fabrication of the nanowire-based nanomotors developed in this study is unique, and this protocol was dependent on the electrochemical preparation of Au nanowires followed by the direct current (DC) magnetron sputtering of Ni part. DC magnetron sputtering-based preparation used for the first time in the literature not only ensured homogeneous distribution and rapid deposition of the metal directly but also provided reproducible thin layers of magnetic Ni resulting in a significant improvement at nanomotor speeds. Besides magnetic propulsion, acoustic propulsion was also successfully applied. The effects of both propusion mechanisms were tested on the speed and direction of Au–Ni nanomotors. Biomedical applications of the motors accomplished in this study are rapid and sensitive detection of an important cancer biomarker microRNA-21 (miRNA-21) and pH-dependent and near-infrared (NIR) triggered release of a commonly used chemotherapeutic drug doxorubicin (DOX). Sensitive and selective miRNA-21 detection was achieved by using dye-labeled single-stranded DNA (ssDNA probe) modified Au–Ni nanomotors with a wide linear concentration range of 0.01 nM to 25 nM. Low detection limits of 2.9 pM and 1.6 pM were obtained for fluorescence and speed-based detection, respectively (n = 3). In addition, magnetically powered DOX-loaded Au–Ni nanomotors were guided on cancer cells (human breast cancer cell lines, MCF-7) in a controllable way for the efficient and controlled delivery of DOX. Cytotoxicity studies of the nanomotors presented negligible influence on the cell viability.

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“…5-FU and CUR-loaded nanocomposites consisting of Pd nanospheres on CS/rGO exhibited sustained release of the drugs and inhibited the growth of human colon cancer cells (HT-29) [ 236 ]. PEGylated nanoceria decorated rGO nanocomposite exhibiting high DOX loading, pH-responsive drug release and a lesser harmful effect on normal cells than cancer cells as compared with free DOX and showed higher cytotoxicity on the cancer cells than the covalently conjugated rGO-PEG-DOX [ 237 ]. Optimized FA-functionalized gelatin-rGO formulation with particle sizes of 300 nm showing chlorambucil EE of 56% released 62.1% and 82% of the total bound drug at pH 5.4 and pH 1.2 respectively, while at pH 7.4 the released amount was 43.7% in the first 24 h. Using a drug-loaded gelatin-rGO nanocomposite, the % viability of human cervical adenocarcinoma cells at application of 500 μg/mL after 24 h achieved 28% compared to 11.7% observed with free drug after 24 h; pronouncedly lower cytotoxicity of chlorambucil-loaded nanocomposites expressed by the IC 50 value compared to the free drug was estimated as well (86 vs. 125.9 μg/mL) [ 238 ].…”

Section: Graphene Oxidementioning

confidence: 99%

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

2021

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Carbon is one of the most abundant elements on Earth. In addition to the well-known crystallographic modifications such as graphite and diamond, other allotropic carbon modifications such as graphene-based nanomaterials and carbon nanotubes have recently come to the fore. These carbon nanomaterials can be designed to help deliver or target drugs more efficiently and to innovate therapeutic approaches, especially for cancer treatment, but also for the development of new diagnostic agents for malignancies and are expected to help combine molecular imaging for diagnosis with therapies. This paper summarizes the latest designed drug delivery nanosystems based on graphene, graphene quantum dots, graphene oxide, reduced graphene oxide and carbon nanotubes, mainly for anticancer therapy.

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Doxorubicin Loaded Green Synthesized Nanoceria Decorated Functionalized Graphene Nanocomposite for Cancer-Specific Drug Release

Cited by 17 publications

References 66 publications

Current Trends and Challenges in Pharmacoeconomic Aspects of Nanocarriers as Drug Delivery Systems for Cancer Treatment

Current Trends and Challenges in Pharmacoeconomic Aspects of Nanocarriers as Drug Delivery Systems for Cancer Treatment

Gold–Nickel Nanowires as Nanomotors for Cancer Marker Biodetection and Chemotherapeutic Drug Delivery

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

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