2023
DOI: 10.1186/s12645-023-00169-8
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Doxorubicin-loaded liposomes surface engineered with the matrix metalloproteinase-2 cleavable polyethylene glycol conjugate for cancer therapy

Abstract: Background Colorectal cancer is one of the prominent leading causes of fatality worldwide. Despite recent advancements within the field of cancer therapy, the cure rates and long-term survivals of patients suffering from colorectal cancer have changed little. The application of conventional chemotherapeutic agents like doxorubicin is limited by some drawbacks such as cardiotoxicity and hematotoxicity. Therefore, nanotechnology has been exploited as a promising solution to address these problems… Show more

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Cited by 18 publications
(3 citation statements)
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“…Preliminary developments in liposome cancer therapy demonstrate potential, but further investigation is required to ascertain their complete capabilities and therapeutic viability. Gaining a comprehensive comprehension of liposome-based cancer treatments is of utmost importance in order to enhance treatment modalities and enhance patient outcomes [ 30 , 52 , 53 , 55 , 56 , 57 , 58 ].…”
Section: Discussionmentioning
confidence: 99%
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“…Preliminary developments in liposome cancer therapy demonstrate potential, but further investigation is required to ascertain their complete capabilities and therapeutic viability. Gaining a comprehensive comprehension of liposome-based cancer treatments is of utmost importance in order to enhance treatment modalities and enhance patient outcomes [ 30 , 52 , 53 , 55 , 56 , 57 , 58 ].…”
Section: Discussionmentioning
confidence: 99%
“…Doxorubicin and paclitaxel are widely used chemotherapy drugs for treating different types of cancer, representing major progress in the field of oncology [ 17 , 61 ]. Integrating them into nanoliposome carriers is a promising approach to improve their effectiveness and lower systemic toxicity [ 53 , 55 ]. Nanoliposomes provide targeted drug delivery due to their small size and biocompatibility, allowing a larger concentration of the drug to reach the tumor site while reducing the exposure of healthy tissues [ 5 ].…”
Section: Discussionmentioning
confidence: 99%
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