Doxorubicin-loaded nanostructured lipid carriers functionalized with folic acid against MCF-7 breast cancer cell line

Costa, Kammila Martins Nicolau; Barros, Rafaela Magalhães; Jorge, Emmily Oliveira; Sato, Mariana Rillo; Chorilli, Marlus; Damasceno, Bolívar Ponciano Goulart de Lima; Nicholas, Dean; Callan, John F.; Oshiro, João Augusto

doi:10.1007/s11051-023-05704-7

Cited by 6 publications

(2 citation statements)

References 42 publications

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“…Figure 1 presents the FTIR spectra showing the different chemical groups of the PF-127 surfactant, sol-gel precursors ( Figure 1 A) as well as of gelatin, tertiary BG using calcium chloride (CaCl 2 ) or calcium ethoxide (Ca(OEt) 2 ) as calcium sources, and their corresponding organic–inorganic nanocomposites with their corresponding digital images ( Figure 1 B). The bands associated with the PF–127 spectrum are characterized by bands at 2877 cm −1 corresponding to the –C–H (aliphatic region), 1473 cm −1 related to the C–C stretching, 1341 cm −1 associated with the O–H plane and 1101 cm −1 (region C–O) with three specific spots at 1061, 1106 and 1145 cm −1 that also suggest C–O–C stretching [ 46 ]. Peaks at 1286 cm −1 and 1287 cm −1 correspond to CH 2 twisting, whereas bands at 956 cm −1 and 840 cm −1 are related to CH 2 wobbling [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

“…The bands associated with the PF–127 spectrum are characterized by bands at 2877 cm −1 corresponding to the –C–H (aliphatic region), 1473 cm −1 related to the C–C stretching, 1341 cm −1 associated with the O–H plane and 1101 cm −1 (region C–O) with three specific spots at 1061, 1106 and 1145 cm −1 that also suggest C–O–C stretching [ 46 ]. Peaks at 1286 cm −1 and 1287 cm −1 correspond to CH 2 twisting, whereas bands at 956 cm −1 and 840 cm −1 are related to CH 2 wobbling [ 46 ]. The sol-gel precursors used were TEOS and TEP, and the calcium sources were CaCl 2 and Ca(OEt) 2 ( Figure 1 A).…”

Section: Resultsmentioning

confidence: 99%

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Sol-Gel Derived Gelatin–Bioactive Glass Nanocomposite Biomaterials Incorporating Calcium Chloride and Calcium Ethoxide

Arambula-Maldonado,

Mequanint

2024

Polymers

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Calcium-containing organic–inorganic nanocomposites play an essential role in developing bioactive bone biomaterials. Ideally, bone substitute materials should mimic the organic–inorganic composition of bone. In this study, the roles of calcium chloride (CaCl2) and calcium ethoxide (Ca(OEt)2) were evaluated for the development of sol-gel-derived organic–inorganic biomaterials composed of gelatin, bioactive glass (BG) and multiwall carbon nanotubes (MWCNTs) to create nanocomposites that mimic the elemental composition of bone. Nanocomposites composed of either CaCl2 or Ca(OEt)2 were chemically different but presented uniform elemental distribution. The role of calcium sources in the matrix of the nanocomposites played a major role in the swelling and degradation properties of biomaterials as a function of time, as well as the resulting porous properties of the nanocomposites. Regardless of the calcium source type, biomineralization in simulated body fluid and favorable cell attachment were promoted on the nanocomposites. 10T1/2 cell viability studies using standard media (DMEM with 5% FBS) and conditioned media showed that Ca(OEt)2-based nanocomposites seemed more favorable biomaterials. Collectively, our study demonstrated that CaCl2 and Ca(OEt)2 could be used to prepare sol-gel-derived gelatin–BG–MWCNT nanocomposites, which have the potential to function as bone biomaterials.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%