Doxorubicin-loaded natural daptomycin micelles with enhanced targeting and anti-tumor effect in vivo

Guo, Quanling; Zhang, Lu; He, Mengmeng; Jiang, Xiaohua; Tian, Jingrui; Li, Qiurong; Liu, Zhiwei; Wang, Longgang; Sun, Hanwen

doi:10.1016/j.ejmech.2021.113582

Cited by 19 publications

(9 citation statements)

References 44 publications

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“…Micelles refer to ordered aggregates of molecules that begin to form in large quantities after surfactant concentration reaches a certain value in aqueous solution. In micelles, hydrophobic groups of surfactant molecules aggregate to form the core of micelles, and hydrophilic polar groups form the outer layer of micelles [66].…”

Section: Micellesmentioning

confidence: 99%

The nano delivery systems and applications of mRNA

et al. 2022

European Journal of Medicinal Chemistry

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Section: Micellesmentioning

confidence: 99%

The nano delivery systems and applications of mRNA

et al. 2022

European Journal of Medicinal Chemistry

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“…For example, these small-molecule drugs generally have poor water solubility, poor tumor-targeting ability, and high toxicity . Researchers have developed a number of drug delivery systems (DDSs) to overcome these shortcomings of traditional small-molecule drugs, , such as liposomes, peptides, , polymer micelles, and dendrimers. , These DDSs reduce drug toxicity and improve drug utilization by enhancing permeability and retention (EPR) effects. , …”

Section: Introductionmentioning

confidence: 99%

Zwitterionic Targeting Doxorubicin -Loaded Micelles Assembled by Amphiphilic Dendrimers with Enhanced Antitumor Performance

et al. 2023

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Chemotherapy is the main method of treating malignant tumors in clinical treatment. However, the commonly used chemotherapeutic drugs have the disadvantages of high biological toxicity, poor water solubility, low targeting ability, and high side effects. Zwitterionic micelles assembled by amphiphilic dendrimers modified with zwitterionic groups and targeting ligand should largely overcome these shortcomings. Herein, the zwitterionic group and targeting peptide c(RGDfC) were modified on the surface of generation 2 poly(propylene imine) dendrimers (G2 PPI), which was conjugated with hydrophobic N-(2-mercaptoethyl) oleamide to form amphiphilic dendrimers (PPIMYRC). PPIMYRC self-assembled into micelles with doxorubicin (DOX) loaded in the interior of micelles to prepare DOX-loaded micelles (PPIMYRC−DOX micelles). The PPIMYRC−DOX micelles had great stability in fibrinogen and pH-responsive drug release. Furthermore, PPIMYRC−DOX micelles had higher cellular uptake rates than free DOX, resulting in higher cytotoxicity of PPIMYRC−DOX micelles than that of free DOX. More importantly, PPIMYRC−DOX micelles inhibited tumors much better than free DOX. The tumor inhibition rate of PPIMYRC−DOX micelles was as high as 93%. Taken together, PPIMYRC−DOX micelles were assembled by amphiphilic dendrimers with the zwitterionic and targeting groups, which enhanced the therapeutic effect of DOX and reduced its side effects. The prepared targeting nanodrug has great potential for further application in antitumor therapy.

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“…In addition, since the tumor sites have a weak acid environment different from that of normal tissues, zwitterionic materials can realize the responsive release of drugs under different pH environments through protonation and deprotonation. 26…”

Section: Introductionmentioning

confidence: 99%