Doxorubicin-loaded pH-responsive chitin nanogels for drug delivery to cancer cells

Preparation and characterisation of gelatin–gum arabic aldehyde nanogels via inverse miniemulsion technique

“…Although synthetic polymers like poly(ethylene glycol) [6], poly(lactic acid) [7] and poly(-caprolactone) [8] proved their ability as suitable materials for development of nanogels, natural polymers like chitosan [9], dextran [10] and hyaluronic acid [11] received more importance owing to their nontoxicity, biocompatibility and biodegradability. Jayakumar and co-workers developed pH responsive chitin and chitosan nanogels and examined the viability for drug delivery to cancer cells, gene therapy, biosensing and bioimaging [12][13][14][15] applications. Pullulan, a highly hydrophilic polysaccharide was hydrophobically modified with cholesterol/spiropyran and self assembled nanogels were prepared from the resultant amphiphilic polysaccharide [16,17].…”

Solvothermal synthesis of hydrophobic chitin–polyhedral oligomeric silsesquioxane (POSS) nanocomposites

“…From a practical point of view, this polysaccharide is a biopolymer with very attractive properties; such as biodegradability, non-toxicity, affinity to peptides, biocompatibility etc. [11] Consequently, these properties contribute to their use in chitin-based materials for a wide range of applications including drug delivery systems [12], tissue engineering [11], enzyme immobilizations [13], waste water treatment [14,15]. The presence of hydroxyl groups in the chitin molecule enables efficient surface modification [16][17][18].…”

Enhanced anti-tumor effect of pH-responsive dextrin nanogels delivering doxorubicin on colorectal cancer

“…The pH-responsive nanogels are cross-linked polymer networks fabricated by incorporating pH-responsive polymers or pH-responsive bonds into their structure (Jayakumar, Nair, Rejinold, Maya, & Nair, 2012;Madhusudana Rao et al, 2013;Morimoto, Hirano, Takahashi, Loethen, Thompson, & Akiyoshi, 2013;Nukolova, Oberoi, Cohen, Kabanov, & Bronich, 2011;Oh et al, 2013;Setty, Deshmukh, & Badiger, 2014). pH-responsive bonds such as hydrazone (Bae, Fukushima, Harada, & Kataoka, 2003;Bae, Nishiyama, & Kataoka, 2007), cis-aconityl (Hu, Liu, Du, & Yuan, 2009;Yoo, Lee, & Park, 2002) and acetal (Bachelder, Beaudette, Broaders, Dashe, & Frechet, 2008) bonds are used as linkers to immobilize anti-tumor drugs within the carrier matrix.…”