Doxorubicin-loaded, pH-sensitive Albumin Nanoparticles for Lung Cancer Cell Targeting

Aziz, A. N.; Sefidbakht, Yahya; Rezaei, Shokouh; Kouchakzadeh, Hasan; Uskoković, Vuk

doi:10.1016/j.xphs.2021.12.006

Cited by 19 publications

(5 citation statements)

References 42 publications

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“…The LC of the samples confirm this trend and showed increasing values confirming the ability of the polymeric matrix to hold the drug. These profiles can result from non-covalent bonds between the protonated amine group of DOX and the negatively-charged carboxyl groups of the polymer, as already described for several other protein-based DOX-loaded nanoformulations [ 49 , 50 , 51 , 52 , 53 ].…”

Section: Resultsmentioning

confidence: 85%

Gliadin Nanoparticles Containing Doxorubicin Hydrochloride: Characterization and Cytotoxicity

et al. 2023

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Doxorubicin hydrochloride (DOX) is a well-known antitumor drug used as first line treatment for many types of malignancies. Despite its clinical relevance, the administration of the compound is negatively affected by dose-dependent off-target toxicity phenomena. Nanotechnology has helped to overcome these important limitations by improving the therapeutic index of the bioactive and promoting the translation of novel nanomedicines into clinical practice. Herein, nanoparticles made up of wheat gliadin and stabilized by polyoxyethylene (2) oleyl ether were investigated for the first time as carriers of DOX. The encapsulation of the compound did not significantly affect the physico-chemical features of the gliadin nanoparticles (GNPs), which evidenced a mean diameter of ~180 nm, a polydispersity index < 0.2 and a negative surface charge. The nanosystems demonstrated great stability regarding temperature (25–50 °C) and were able to retain high amounts of drug, allowing its prolonged and sustained release for up to a week. In vitro viability assay performed against breast cancer cells demonstrated that the nanoencapsulation of DOX modulated the cytotoxicity of the bioactive as a function of the incubation time with respect to the free form of the drug. The results demonstrate the potential use of GNPs as carriers of hydrophilic antitumor compounds.

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Section: Resultsmentioning

confidence: 85%

Gliadin Nanoparticles Containing Doxorubicin Hydrochloride: Characterization and Cytotoxicity

et al. 2023

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“…In an effort, pH-sensitive albumin nanoarchitectures were developed for DOX delivery in lung cancer suppression. These nanoparticles released DOX at a pH lower than physiological pH and this promoted accumulation of anti-tumor agent in tumor site, resulting in apoptosis 42 . Another study synthesized pH-sensitive polymerosomes for DOX delivery and glioblastoma treatment.…”

Section: Resultsmentioning

confidence: 99%

Multifunctional green synthesized Cu–Al layered double hydroxide (LDH) nanoparticles: anti-cancer and antibacterial activities

Kiani

Bagherzadeh

Ghadiri

et al. 2022

Sci Rep

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Doxorubicin (DOX) is a potent anti-cancer agent and there have been attempts in developing nanostructures for its delivery to tumor cells. The nanoparticles promote cytotoxicity of DOX against tumor cells and in turn, they reduce adverse impacts on normal cells. The safety profile of nanostructures is an important topic and recently, the green synthesis of nanoparticles has obtained much attention for the preparation of biocompatible carriers. In the present study, we prepared layered double hydroxide (LDH) nanostructures for doxorubicin (DOX) delivery. The Cu–Al LDH nanoparticles were synthesized by combining Cu(NO3)2·3H2O and Al(NO3)3·9H2O, and then, autoclave at 110. The green modification of LDH nanoparticles with Plantago ovata (PO) was performed and finally, DOX was loaded onto nanostructures. The FTIR, XRD, and FESEM were employed for the characterization of LDH nanoparticles, confirming their proper synthesis. The drug release study revealed the pH-sensitive release of DOX (highest release at pH 5.5) and prolonged DOX release due to PO modification. Furthermore, MTT assay revealed improved biocompatibility of Cu–Al LDH nanostructures upon PO modification and showed controlled and low cytotoxicity towards a wide range of cell lines. The CLSM demonstrated cellular uptake of nanoparticles, both in the HEK-293 and MCF-7 cell lines; however, the results were showed promising cellular internalizations to the HEK-293 rather than MCF-7 cells. The in vivo experiment highlighted the normal histopathological structure of kidneys and no side effects of nanoparticles, further confirming their safety profile and potential as promising nano-scale delivery systems. Finally, antibacterial test revealed toxicity of PO-modified Cu–Al LDH nanoparticles against Gram-positive and -negative bacteria.

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“…Among various protein nano-carrier materials reported, albumin has many advantages such as water solubility, biodegradability, biocompatibility, non-toxicity, non-immunogenicity characteristics, and particularly tumor targeting ability, thereby it is a very promising protein nano-carrier material to ensure the chemotherapy efficacy and safety of anti-tumor drugs (Kunde & Wairkar, 2022 ). Protein nano-delivery system is easy to modify the surface, using magnetic materials, pH-responsive materials, or connecting targeting ligands, to further enhance the targeting and curative effect of drug-loaded nanoparticles (Aziz et al., 2022 ).…”

Section: Pharmaceutical Designs Of Dhmmentioning

confidence: 99%

Strategic developments in the drug delivery of natural product dihydromyricetin: applications, prospects, and challenges

et al. 2022

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Dihydromyricetin (DHM) is an important natural flavonoid that has attracted much attention because of its various functions such as protecting the cardiovascular system and liver, treating cancer and neurodegenerative diseases, and anti-inflammation effect, etc. Despite its great development potential in pharmacy, DHM has some problems in pharmaceutical applications such as low solubility, permeability, and stability. To settle these issues, extensive research has been carried out on its physicochemical properties and dosage forms to produce all kinds of DHM preparations in the past ten years. In addition, the combined use of DHM with other drugs is a promising strategy to expand the application of DHM. However, although invention patents for DHM preparations have been issued in several countries, the current transformation of DHM research results into market products is insufficient. To date, there is still a lack of deep research into the pharmacokinetics, pharmacodynamics, toxicology, and action mechanism of DHM preparations. Besides, preparations for combined therapy of DHM with other drugs are scarcely reported, which necessitates the development of dosage forms for this application. Apart from medicine, the development of DHM in the food industry is also of great potential. Due to its multiple effects and excellent safety, DHM preparations can be developed for functional drinks and foods. Through this review, we hope to draw more attention to the development potential of DHM and the above challenges and provide valuable references for the research and development of other natural products with a similar structure-activity relationship to this drug.

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Doxorubicin-loaded, pH-sensitive Albumin Nanoparticles for Lung Cancer Cell Targeting

Cited by 19 publications

References 42 publications

Gliadin Nanoparticles Containing Doxorubicin Hydrochloride: Characterization and Cytotoxicity

Gliadin Nanoparticles Containing Doxorubicin Hydrochloride: Characterization and Cytotoxicity

Multifunctional green synthesized Cu–Al layered double hydroxide (LDH) nanoparticles: anti-cancer and antibacterial activities

Strategic developments in the drug delivery of natural product dihydromyricetin: applications, prospects, and challenges

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