Doxorubicin-loaded poly(butylcyanoacrylate) nanoparticles produced by emulsifier-free emulsion polymerization

Abstract

Doxorubicin‐loaded poly(butylcyanoacrylate) (PBCA) nanoparticles (NPs) were prepared by an emulsifier‐free emulsion polymerization technique. The pH values of the polymerization medium and the weight ratios of doxorubicin to butylcyanoacrylate had a significant effect on the mean particle size. The particle diameter determined by transmission electron microscopy showed that the nanoparticles were predominantly less than 50 nm. Drug loading and entrapment efficiency increased with increasing pH of the medium. The surface tension of the polymerization media increased with increasing polymerization time and reached a plateau after 4 h. Doxorubicin‐loaded PBCA NPs carried a positive charge, and the zeta potential of drug‐loaded nanoparticles increased with the increase of the polymerization pH. Molecular weight, analyzed by gel permeation chromatography, showed that the nanoparticles mainly consisted of oligomers of PBCA. The release rate of doxorubicin from nanoparticles in biological phosphate buffer was very slow, with a half‐life of 111.43 h. The results indicate that drug‐loaded nanoparticles can be prepared by an emulsifier‐free emulsion polymerization technique and that the resulting nanoparticles might be suitable for targeting drug delivery vehicles for clinical application. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 78: 517–526, 2000

Mathematical modeling of drug release from swellable polymeric nanoparticles

“…This study provides valuable evidence for the practicable use of the Weibull model in drug release phenomena from swellable polymeric nanoparticles. Likely there are also several studies have experimentally investigated that, the release data from swellable polymeric nanoparticles fit best with the weibull model (Yang et al, 2000;Adibkia et al, 2007;Aksungur et al, 2011;Ji et al, 2011;Bei et al, 2012;Azadi et al, 2013;Sun et al, 2014;Liu et al, 2015;Ashrafi and Azadi, 2016;Jafari-Aghdam et al, 2016). Among the studied models, Weibull is regarded as a favorable model which includes parameters that are sensitive to ranges of release profile.…”

H-ferritin–nanocaged doxorubicin nanoparticles specifically target and kill tumors with a single-dose injection

“…The loading of Dox into the HFn nanocages is dependent on their electrostatic interactions. Because the pK a of Dox is 8.2 (31), it can easily bind to the negatively charged internal surface of ferritin (32) in the neutral loading buffer. Size-exclusion chromatography confirmed the successful loading of Dox into HFn nanocages, and the amount of encapsulated Dox was determined to be 33 Dox molecules per HFn nanocage (Fig.…”

Green Preparation Process, Characterization and Antitumor Effects of Doxorubicin–BSA–Dextran Nanoparticles

“…The precipitates in doxorubicin/BSA mixture solution indicate the formation of doxorubicin/BSA complexes. As the p K a of doxorubicin is 8.2,33 most of the doxorubicin molecules carry positive charges at pH 7.4. On the other hand, BSA carries negative charges when the solution pH is above 4.8, the isoelectric point of BSA.…”