Doxorubicin pharmacokinetics following a single‐dose infusion to sulphur‐crested cockatoos (Cacatua galerita)

Abstract

Doxorubicin infusion in sulphur-crested cockatoos produced mild, transient inappetence. The volume of distribution per kilogram and terminal half-life were considerably smaller, but the clearance per kilogram was similar to or larger than reported in the dog, rat and humans. Traces of doxorubicinol, a metabolite of doxorubicin, were detected in the plasma.

Pharmacokinetics of doxorubicinol in dogs

“…(1984) for doxorubicin. These findings are consistent with the relatively greater polarity of doxorubicinol, and support the results of a doxorubicin pharmacokinetic study in Australian sulphur‐crested cockatoos ( Cacatua galerita ) (Gilbert et al. , 2004).…”

“…Part of the dose is converted by cyctoplasmic NADPH‐dependent aldoketoreductase to a cytotoxic 13‐hydroxyl metabolite, doxorubicinol, which circulates in appreciable concentrations in mammals (Speth et al. , 1988), and birds (Gilbert et al. , 2004; Gilbert, 2004), and which is suspected to be responsible for cardiotoxicity seen in some human patients given doxorubicin (Olsen et al.…”

“…Also, the half‐life of doxorubicinol is likely to be overestimated in such circumstances as it appears to have formation rate‐limited kinetics (Speth et al. , 1988; Gilbert et al. , 2004).…”

“…Therefore, the metabolite kinetics are always confounded with the parent drug. Also, the half-life of doxorubicinol is likely to be overestimated in such circumstances as it appears to have formation rate-limited kinetics (Speth et al, 1988;Gilbert et al, 2004).…”

Simultaneous liquid chromatographic determination of doxorubicin and its major metabolite doxorubicinol in parrot plasma

“…3 were analysed using established non-parametric methods. The pharmacokinetic results for this bird were: clearance, 2.46 L/h; volume of distribution, 240 mL; terminal phase half-life, 2.38 h; mean residence time, 5.89 min; area-under-the-curve, 520 g/L h. Our studies of the pharmacokinetics of doxorubicin and doxorubicinol in parrots are described more fully elsewhere [10].…”