Doxorubicin Release from PHEMA Nanoparticles

Chouhan, Raje; Bajpai, Aman

doi:10.1201/b12223-9

Cited by 6 publications

(10 citation statements)

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“…The thermal ablation effect was particularly effective on the cells targeted by the nanotubes functionalized with the combination of the two antibodies. Similar results were achieved by Xiao et al, 26 but in this case the authors attached covalently the anti-HER2 antibody to oxidized SWCNTs aer activation of the carboxylic groups (Fig. 2B).…”

Section: Cancer Immunotherapysupporting

confidence: 82%

Carbon nanomaterials as new tools for immunotherapeutic applications

2014

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Carbon-based nanomaterials, including carbon nanotubes and graphene, have gained great attention in the scientific community due to their unique physico-chemical properties, which could be also promising in many biomedical-related fields. In particular, their low cytotoxicity, achieved when properly functionalized, along with the possibility to link multiple bioactive molecules, realistically allows envisaging their potential use as a therapeutic platform. In this context, the immune system and immune responses play an important role in our organism, as they are involved either directly or indirectly in many diseases. Therefore, the possibility to prevent or block a disease by controlling and/or modulating the immune responses has become an important task in nanomedicine. In this feature article the advantages of using carbon-based materials in immunotherapy are presented. Important goals achieved using carbon nanotubes and graphene are described, highlighting the promising use of these nanomaterials in cancer treatment, imaging and vaccine development. The capacity of functionalized carbon nanotubes to modulate the immune responses is also discussed, highlighting the current state of the art and the future developments on this subject.

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Section: Cancer Immunotherapysupporting

confidence: 82%

Carbon nanomaterials as new tools for immunotherapeutic applications

2014

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“…SWCNTs absorb light strongly in the near-infrared (NIR) range (800-1600 nm), which contains the tissue transparent region of electromagnetic wavelengths (800-1400 nm). Therefore, they are extensively employed in photothermal therapy [33][34][35] and photoacoustic imaging [36]. The optical properties of SWCNTs can also be used for Raman detection and imaging [34,37,38].…”

Section: 2mentioning

confidence: 99%

“…Anti-HER2 chicken IgY was covalently bound to carboxyl-SWCNT for in vitro detection and selective killing of SK-BR-3 (cancer cells expressing HER2) in the presence of MCF-7 (non-HER2 expressing) cells [34]. The detection concept is based on the strong resonance at Raman scattering of SWCNTs [112], while the therapeutic effect is based on the NIR absorbance for the selective photothermal excision of cancer cells [35].…”

Section: (2011) 4077-4097mentioning

confidence: 99%

Delivery of drugs and biomolecules using carbon nanotubes

Vashist

Zheng

Pastorin

et al. 2011

Carbon

253

127

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Carbon nanotubes (CNTs) have emerged as one of the most advanced nanovectors for the highly efficient delivery of drugs and biomolecules. They offer several appealing features such as large surface areas with well defined physico-chemical properties as well as unique optical and electrical properties. They can be conjugated non-covalently or covalently with drugs, biomolecules and nanoparticles. Albeit some pending concerns about their toxicity in vitro and in vivo, functionalized CNTs appear to exhibit very low toxicity and are not immunogenic. Thus, they could be promising carriers with a great potential for the development of a new-generation delivery system for drugs and biomolecules. There have been significant advances in the field of CNT-based drug delivery, especially in the specific targeting of anticancer and anti-inflammatory drugs for tissues and organs in the body, where their therapeutic effect is highly required. Other promising applications are the delivery of DNA, RNA and proteins.Crown

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“…Recently, a few studies have demonstrated that immuno‐CNT constructs (antibody (Ab)–CNT conjugates) can modulate immunological functions, provide specific targeting, and enhance the efficacy of antitumor therapies 15–25. In the last example CNTs were associated with an antineoplastic drug15 or with a radiotherapeutic agent21 combined with an Ab to selectively target cancer cells, thus limiting the cellular damage of healthy tissues and increasing the specific delivery of the therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

B‐Ring‐Modified isoCombretastatin A‐4 Analogues Endowed with Interesting Anticancer Activities

et al. 2011

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A novel class of isocombretastatin A-4 (isoCA-4) analogues with modifications at the 3'-position of the B-ring by replacement with C-linked substituents was studied. Exploration of the structure-activity relationships of theses analogues led to the identification of several compounds that exhibit excellent antiproliferative activities in the nanomolar concentration range against H1299, MDA-MB231, HCT116, and K562 cancer cell lines; they also inhibit tubulin polymerization with potency similar to that of isoCA-4. 1,1-Diarylethylenes 8 and 17, respectively with (E)-propen-3-ol and propyn-3-ol substituents at the 3'-position of the B-ring, proved to be the most active in this series. Both compounds led to the arrest of various cancer cell lines at the G(2) /M phase of the cell cycle and strongly induced apoptosis. Docking of compounds 8 and 17 in the colchicine binding site indicated that their C3' substituents guide the positioning of the B-ring in a manner different from that observed for isoCA-4.

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Doxorubicin Release from PHEMA Nanoparticles

Cited by 6 publications

References 0 publications

Carbon nanomaterials as new tools for immunotherapeutic applications

Carbon nanomaterials as new tools for immunotherapeutic applications

Delivery of drugs and biomolecules using carbon nanotubes

B‐Ring‐Modified isoCombretastatin A‐4 Analogues Endowed with Interesting Anticancer Activities

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