Doxorubicin Uptake and Release from Microgel Thin Films

Serpe, Michael J.; Yarmey, Kristen A.; Nolan, Christine M.; Lyon, L. Andrew

doi:10.1021/bm049455x

Cited by 220 publications

(190 citation statements)

References 32 publications

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“…In addition to the release of macromolecules, these films have also been used for releasing small drug molecules such as doxorubicin. [84] Unlike in the insulin case, these films were first fabricated and then loaded with doxorubicin by thermal cycling. Similar results were obtained for the doxorubicin loaded films, where film deswelling resulted in the expulsion of the drug over many thermal cycles.…”

Section: Soft Nanotechnologymentioning

confidence: 99%

Soft Nanotechnology with Soft Nanoparticles

2005

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The last decade of research in the physical sciences has seen a dramatic increase in the study of nanoscale materials. Today, "nanoscience" has emerged as a multidisciplinary effort, wherein obtaining a fundamental understanding of the optical, electrical, magnetic, and mechanical properties of nanostructures promises to deliver the next generation of functional materials for a wide range of applications. While this range of efforts is extremely broad, much of the work has focused on "hard" materials, such as Buckyballs, carbon nanotubes, metals, semiconductors, and organic or inorganic dielectrics. Meanwhile, the soft materials of current interest typically include conducting or emissive polymers for "plastic electronics" applications. Despite the continued interest in these established areas of nanoscience, new classes of soft nanomaterials are being developed from more traditional polymeric constructs. Specifically, nanostructured hydrogels are emerging as a promising group of materials for multiple biotechnology applications as the need for advanced materials in the post-genomic era grows. This review will present some of the recent advances in the marriage between water-swellable networks and nanoscience.

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Section: Soft Nanotechnologymentioning

confidence: 99%

Soft Nanotechnology with Soft Nanoparticles

2005

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“…[14,15] Charged pNIPAm-based microgels have been synthesized and used for various applications. [16][17][18] By far, the most common chemical functionality added to pNIPAm-based microgels is acrylic acid (AAc). AAc is a weak acid, having a pK a of approximately 4.25, therefore at pH > 4.25 the AAc groups are deprotonated, thus making the microgels negatively charged (polyanionic), while they are neutral at pH < 4.25 owing to AAc protonation.…”

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confidence: 99%

Polymer‐Based Muscle Expansion and Contraction

et al. 2013

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Weight lifting: A polymer‐based device capable of lifting many times its own mass was fabricated by drying a solution of the polycation poly(diallyldimethyl ammonium chloride) (pDADMAC) on a surface coated with charged poly(N‐isopropylacrylamide)‐based microgels. Upon drying of the pDADMAC solution on the microgel‐modified surface, it bends. Flexible surfaces then curl up into scroll‐like structures, which can be opened up at high humidity.

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“…in response to temperature changes across the LCST. These unique features make PNIPAM particles desirable for numerous applications, including controlled drug delivery, 11,12 control of enzymatic activity, 13,14 tunable optics, 15,16 and bioseparation. 17 Colloidally stable PNIPAM particles were first prepared by precipitation polymerization of NIPAM with N,N 0 -methylenebisacryamide (MBAAm) as a cross-linking agent in an aqueous medium at 60 to 70 C. 18 The resulting particles showed a volume phase transition at the LCST around 32 C. In precipitation polymerization, the initial state of the reaction mixture is a homogeneous solution.…”

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Preparation and Characterization of Micrometer-Sized Poly(N-isopropylacrylamide) Hydrogel Particles

2009

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The present study deals with preparation and swelling properties of micrometer-sized poly(N-isopropylacrylamide) (PNIPAM) hydrogel particles. Aqueous precipitation polymerization of NIPAM with N,N 0 -methylenebisacrylamide (MBAAm) was performed with varying electrolyte concentrations in the polymerization media. Sodium chloride was used as an electrolyte. According to the particle size analysis by transmission electron microscope, the particle size increased in the range of 0.55 to 1.60 mm with an increase in the electrolyte concentration up to 1.6 wt %. The concentration is based on the NIPAM monomer weight. Dynamic light scattering data showed that swelling ratio of PNIPAM hydrogel particles in water varied from 10 to 40 as the electrolyte concentration at particle preparation increased from 0 to 1.6 wt %. Time-course analysis of particle size showed that an increase in particle size would be caused by aggregation of smaller particles. In conclusion, micrometer-sized PNIPAM particles with high swelling capacity can be obtained by the addition of an electrolyte in polymerization media. Thermosensitive hydrogel particles containing poly(N-isopropylacrylamide) (PNIPAM) moieties have attracted much attention because they exhibit sharp and reversible volume phase transition at the lower critical solution temperature (LCST).1,2 PNIPAM particles also show the dramatic change of their colloidal properties such as hydrophobicity, 3 particle size, 4 electrophoretic mobility, 5,6 colloidal stability, 7,8 rheology 9,10 etc. in response to temperature changes across the LCST. These unique features make PNIPAM particles desirable for numerous applications, including controlled drug delivery, 11,12 control of enzymatic activity, 13,14 tunable optics, 15,16 and bioseparation. 17 Colloidally stable PNIPAM particles were first prepared by precipitation polymerization of NIPAM with N,N 0 -methylenebisacryamide (MBAAm) as a cross-linking agent in an aqueous medium at 60 to 70 C. 18 The resulting particles showed a volume phase transition at the LCST around 32 C. In precipitation polymerization, the initial state of the reaction mixture is a homogeneous solution. When a water-soluble initiator is added to the mixture, initiation and propagation take place largely in the homogeneous medium, followed by phase separation of growing PNIPAM chains because PNIPAM is insoluble in the medium at the reaction temperature. This leads to continuous nucleation and coagulation of the resulting nuclei to form larger particles. Since the first report, various methods have been studied so far for preparation of PNIPAM hydrogel particles. Pelton and co-workers reported that addition of surfactant gave smaller and more uniform PNIPAM particles than those obtained without surfactant.19 Yi et al. reported that monodisperse thermosensitive poly(styrene-co-NIPAM) particles with diameters in the range of 100 to 130 nm could be prepared by emulsifier-free emulsion polymerization with microwave irradiation. 20 In addition, many researchers have focuse...

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Doxorubicin Uptake and Release from Microgel Thin Films

Cited by 220 publications

References 32 publications

Soft Nanotechnology with Soft Nanoparticles

Soft Nanotechnology with Soft Nanoparticles

Polymer‐Based Muscle Expansion and Contraction

Preparation and Characterization of Micrometer-Sized Poly(N-isopropylacrylamide) Hydrogel Particles

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