Doxycycline For Chronic Driveline Infections Can Cause Diabetes Insipidus

Kesari, Aditya; Schreck, Tara; Benatti, Rodolfo D; Basuray, Anupam

doi:10.1016/j.cardfail.2022.10.171

Cited by 3 publications

(2 citation statements)

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“…The presented case highlights the challenges in managing hyponatremia associated with SCLC in the absence of the recommended medications. Doxycycline, a tetracycline similar to demeclocycline, was utilized as an alternative due to its potential association with diabetes insipidus [4][5] which can impair urine concentrating ability and help address the hyponatremia.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, doxycycline, another member of the tetracycline class, has also been associated with the development of diabetes insipidus (DI) and functional aquaporin deficiency. Case reports have described DI occurring in a patient treated with doxycycline for cellulitis and another patient receiving suppressive antibiotic therapy for left ventricle assist device (LVAD) driveline infections [4][5]. These cases highlight the potential link between doxycycline use and DI, as both patients experienced excessive diuresis following doxycycline administration.…”

Section: Discussionmentioning

confidence: 99%

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Overcoming Challenges: Doxycycline as an Alternative Treatment for Hyponatremia in Managing Syndrome of Inappropriate Secretion of Anti-diuretic Hormone (SIADH) in Small Cell Lung Cancer (SCLC): A Case Report

Imran,

Zia,

Siddiqi

et al. 2023

Cureus

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Hyponatremia, a common complication in small cell lung cancer (SCLC), can arise from various causes such as cancer itself, its treatment, paraneoplastic syndrome-induced SIADH secretion (syndrome of inappropriate anti-diuretic hormone secretion), and brain metastasis. While fluid restriction is the initial approach, refractory cases require pharmacological intervention in managing hyponatremia secondary to SIADH. This case report presents doxycycline as an alternative treatment option for a patient with refractory hyponatremia and SCLC with brain metastases, resulting in improved serum sodium levels. However, the use of doxycycline was associated with acute pancreatitis, prompting its discontinuation without establishing a definitive causal relationship. This case report highlights the importance of alternative treatments in resource-limited settings and emphasizes personalized care for hyponatremia in SCLC patients. Doxycycline can be an option, but safety and effectiveness require further study.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Overcoming Challenges: Doxycycline as an Alternative Treatment for Hyponatremia in Managing Syndrome of Inappropriate Secretion of Anti-diuretic Hormone (SIADH) in Small Cell Lung Cancer (SCLC): A Case Report

Imran,

Zia,

Siddiqi

et al. 2023

Cureus

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Doxycycline

2023

Reactions Weekly

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Fixed Drug Eruption Due to Doxycycline Postexposure Prophylaxis

Nguyen,

Diamond

2024

Pharmacoepidemiology

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Doxycycline is a semi-synthetic antibiotic in the tetracycline family. The three common subtypes of tetracyclines include naturally occurring, semi-synthetic, and new agents. Each subtype shares specific commonalities but is substantially different in various clinical applications. The mechanism of antimicrobial activity is the same across subtypes. The structural changes to the core naphthacene ring do not alter the mechanism of action but are thought to alter the rates of adverse effects and mechanisms of resistance. Tetracyclines as a class are known to cause fixed drug eruptions, but the majority of these adverse effects were associated with naturally occurring tetracyclines. Semi-synthetic tetracyclines have limited reports of fixed drug eruptions. Here, we present a case of fixed drug eruption in a patient who previously had multiple treatment courses with doxycycline. The case involves the use of doxycycline not for the treatment of an infection but as postexposure prophylactic (PEP) antibiotic therapy to prevent the acquisition of a sexually transmitted infection. Doxycycline PEP has been shown to reduce the rate of bacterial sexually transmitted infection in men who have sex with men (MSM). Doxycycline PEP is a single dose taken orally within 24–72 h of unprotected sexual intercourse. The dosing structure allows for ease of adherence but also repeatedly exposes individuals to doxycycline, putting them at risk for adverse events such as fixed drug eruptions, as illustrated by this case report.

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Doxycycline For Chronic Driveline Infections Can Cause Diabetes Insipidus

Cited by 3 publications

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Overcoming Challenges: Doxycycline as an Alternative Treatment for Hyponatremia in Managing Syndrome of Inappropriate Secretion of Anti-diuretic Hormone (SIADH) in Small Cell Lung Cancer (SCLC): A Case Report

Overcoming Challenges: Doxycycline as an Alternative Treatment for Hyponatremia in Managing Syndrome of Inappropriate Secretion of Anti-diuretic Hormone (SIADH) in Small Cell Lung Cancer (SCLC): A Case Report

Doxycycline

Fixed Drug Eruption Due to Doxycycline Postexposure Prophylaxis

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