Doxycycline‐induced oesophageal ulcer in a teenager: A case report

Rawahi, Yusriya Al; Dutt, Shoma

doi:10.1111/jpc.14561

Cited by 3 publications

(2 citation statements)

References 5 publications

(20 reference statements)

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“…In addition, patient position, the size of the pill, and the amount of water ingested are important determinant risk factors [6]. Doxycycline, in particular, is a relatively large-sized pill with a low pH (pH of <3) [7]. Our patient took a capsule formulation of doxycycline, which has been shown to remain in the esophagus three times longer than its tablet form [3,6].…”

Section: Discussionmentioning

confidence: 94%

Esophageal Ulceration Following the Ingestion of a Single Dose of Doxycycline: A Case Report

Almayoof,

Abbarh,

Mohammed

et al. 2024

Cureus

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Doxycycline is one of the medications that cause drug-induced esophagitis. This condition occurs due to prolonged contact of the medications with the esophageal mucosa, leading to erosion, ulcers, and, in some cases, stricture of the esophagus. Chest pain, dysphagia, and odynophagia are the most common symptoms. Endoscopy is the gold standard for confirming the diagnosis. The treatment consists of stopping the offending medication and starting proton pump inhibitors (PPIs) and sucralfate. Herein, we describe a middle-aged man who presented with severe chest pain, odynophagia, and dysphagia that started two hours after ingesting the first doxycycline pill. An endoscopy showed multiple longitudinal ulcers in the distal esophagus. Symptoms significantly improved after starting a PPI and sucralfate, and feeding was resumed two days later. A follow-up with endoscopy after two months reported completely healed esophageal ulcers. In conclusion, doxycycline-induced esophageal injury is often an underdiagnosed and underreported condition. Physicians and patients should be more aware of doxycycline's detrimental effect on the esophagus, as it can induce esophageal ulceration even after a single dose if not administered properly. Therefore, all patients prescribed oral doxycycline should receive appropriate instructions to minimize this side effect.

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Section: Discussionmentioning

confidence: 94%

Esophageal Ulceration Following the Ingestion of a Single Dose of Doxycycline: A Case Report

Almayoof,

Abbarh,

Mohammed

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“…Although our case presented esophageal symptoms, we still decided to initiate a treatment with doxycycline because of its clinical efficacy. Indeed, doxycycline could be responsible for esophageal injuries with esophagitis, ulcer, or stenosis that may occur during the treatment due to doxycycline's pH being below 3 ( Al Rawahi and Dutt, 2019 ).…”

Section: Discussionmentioning

confidence: 99%