Doxycycline-induced ulceration mimicking esophageal cancer

Tahan, Veysel; Sayrak, Hakan; Bayar, Nevzat; Erer, Burak; Tahan, Gülgün; Dane, Faysal

doi:10.1186/1757-1626-1-144

Cited by 23 publications

(17 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the upper endoscopy, we found that most of the ulcers were located in the middle third of the esophagus, which is compatible with the literature (2,13). Although the histopathological examination of PE is rarely pathognomonic, it is generally nonspecific and includes mostly benign ulcer and acute inflammatory changes (12,16,(22)(23)(24). However, histological evaluation should be performed for differential diagnosis, especially in cases where malignancy and infectious pathologies are suspected.…”

supporting

confidence: 88%

Drug-induced esophageal ulcers: Case series and the review of the literature

Dağ

Öztürk²,

Akin³

et al. 2014

Turk J Gastroenterol

View full text Add to dashboard Cite

, by excluding other factors, 48 patients were included in the study, diagnosed as drug-induced esophagitis with their history, endoscopic view, and histopathologic evaluation. Results: There were 34 (70.9%) female and 14 (29.1%) male patients in the study, and their average ages were 35.1 and 32.4, respectively. Clinical symptoms were odynophagia (79.1%), retrosternal pain (62.5%), and dysphagia (47.9%). The reason for these symptoms for 85.5% of the patients was related to insufficient water consumption while taking the pill, taking the pill in recumbent position, or both. Tetracycline and its variant, doxycycline, were responsible for 52% of the patients, and 62.5% of the drugs were in capsule form. Ulcers were at the proximal and middle third of the esophagus in 79.2% of the patients. In the histopathologic evaluation, nonspecific acute inflammatory changes were found in 29.1% of the cases. Various proton pump inhibitors and sucralfate were used in the treatment. While no perforation and structure were detected, 1 patient died because of repetitive arterial bleeding. Conclusion: Almost every kind of drug, particularly doxycycline, can cause ulcer in the esophagus. Pill esophagitis can be prevented by warning patients about drinking water sufficiently and sitting up while taking the pill.

show abstract

supporting

confidence: 88%

Drug-induced esophageal ulcers: Case series and the review of the literature

Dağ

Öztürk²,

Akin³

et al. 2014

Turk J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Crohn's disease) or esophageal cancer as in some patients esophageal lesions may appear endoscopicaly as malignant lesions. [16] In most cases treatment of pill-induced esophagitis implies discontinuing the causative agent. In order to prevent such injuries or for patients who wish/have to continue these treatments the risk of esophageal lesions can be reduced by taking medications with 200-250 ml of water, taking medications if possible in the morning and remaining in upright position for at least 30 min after swallowing the tablet or until food is ingested.…”

Section: Medication Inducing Esophageal Injurymentioning

confidence: 99%

Adverse effects of drugs on the esophagus

Tutuian

2010

Best Practice & Research Clinical Gastroenterology

View full text Add to dashboard Cite

“…Iron tablets [2], doxycycline [3], cyproterone acetate and ethinylestradiol [4] are all described to have led to painful esophagitis. Even a presentation of esophageal cancer-like symptoms after doxycycline intake is described by Tahan et al [5]. There is little information regarding discoloration of the gastric antrum and duodenal bulb, despite their known propensity to be a hot spot for bleedings, ulcerations, and tumors.…”

Section: Discussionmentioning

confidence: 99%

Chemical gastritis after chronic bromazepam intake: a case report

et al. 2010

View full text Add to dashboard Cite

BackgroundWe describe a rare case of diffuse macroscopic discoloration and chemical gastritis due to chronic bromazepam intake. The chemical composition of pharmaceuticals has to be considered at endoscopy and it is evident that some chemical substances damage the epithelial tissue and lead to clinical symptoms.Case PresentationEndoscopy was performed in an 82-year-old patient due to gastroesophageal reflux symptoms and epigastric pain. Gastroscopy showed a hiatal hernia and a scarred duodenal bulb. More striking was the yellow-brownish discoloration of the gastric and the duodenal mucosa. The gastric antrum and the duodenal bulb showed local discoloration that could not be rinsed off. The medical history indicated that bromazepam (6 mg) had been used daily as a sleeping aid in the previous two years. The histopathological findings showed appearances of chemical gastritis. Within the lamina propria and on the epithelial surface there were granules. There was no foreign body reaction to these granules. Corpus mucosa showed a mild chronic gastritis.ConclusionsIf discoloration of the mucosa at endoscopy is seen, a careful drug history must be sought. This is the first case in literature that shows a chemical gastritis after bromazepam intake.

show abstract

Doxycycline-induced ulceration mimicking esophageal cancer

Cited by 23 publications

References 5 publications

Drug-induced esophageal ulcers: Case series and the review of the literature

Drug-induced esophageal ulcers: Case series and the review of the literature

Adverse effects of drugs on the esophagus

Chemical gastritis after chronic bromazepam intake: a case report

Contact Info

Product

Resources

About