Doxycycline pharmacokinetics in geese

Abstract

Infection with Mycoplasma species is one of the main causes of significant economic loss in the domestic goose industry worldwide, causing reduced growth and egg production, and increased mortality and treatment costs (Stipkovits and Szathmary, 2012;Yadav et al., 2021). Waterfowl meat and eggs are highly valued in different countries worldwide, primarily due to their high nutritional quality.France, for instance, is the world's second-largest duck and goose meat consumer, being exceeded only by China Pingel, 2004). Moreover, wild birds, included ducks and geese, may play an important role as potential reservoirs and vectors of Mycoplasma species to the detriment of other domestic poultry. M. gallisepticum and M. synovitis are the most relevant strains among Mycoplasma species in poultry and are recognized as respiratory pathogens by the World Organization for Animal Health (OIE, 2018). Mycoplasma species are sensitive to a variety of antibacterials, including tetracyclines. Doxycycline is a semisynthetic tetracycline derivative with a broad spectrum of bacteriostatic activity. It acts by binding to the bacterial 30S ribosomal subunit, inhibiting

Veterinary pharmacology: A world almost unexplored with huge potential

“…Thus, the support of independent scientists results of paramount importance in order to expand the knowledges even in niche areas of the veterinary field. Recent examples of that have been reported in geese ( Sartini et al., 2020a , 2020 b , 2021a ,2021 b , 2021 c , 2022b ) and crocodiles ( Poapolatep et al., 2017 ; 2020a ,2020 b , 2020 c , 2020 d , 2022a , 2022b) both considered minor species at global level. A long series of drugs have been tested by independent scientists introducing new important data in animals that have been ignored so far.…”