Doxycycline pharmacokinetics in mammalian species of veterinary interest – an overview

Abstract

Doxycycline is a broad-spectrum tetracycline antibiotic widely used in veterinary medicine. The current review aims to summarise the available data about pharmacokinetics in mammalian species of veterinary interest and to indicate the basic strategies for refining dosage regimens in order to use this antibiotic reasonably. Additionally, the available data about population pharmacokinetics are reviewed as this approach exhibits a number of benefits in terms of determination of drug phar­ma­cokinetics, prediction of drug disposition and interpretation of the variations in the pharmacokinetic parameters. Further research with animal species of veterinary interest and pathogens causing diseases in animals is needed to clarify the pharmacokinetics and pharmacodynamics of doxycycline.

Pharmacokinetics of doxycycline hyclate in pigs with a new feed premix formulation

“…In this respect, the prototype of doxycycline hyclate used in this trial is presented as a viable proposal that merits further analysis. Hence, it must be tested in different breeds (including minipigs) and sexes, and clinical and pharmacokinetic comparative studies would be necessary with other tetracyclines (Mileva & Milanova, 2022).…”