Doxycycline sclerodesis as a treatment option for persistent Morel-Lavallée lesions

Bansal, Abhishek; Bhatia, Naval; Singh, Archana; Singh, Ashwani Kumar

doi:10.1016/j.injury.2011.11.024

Cited by 98 publications

(116 citation statements)

References 14 publications

Supporting

Mentioning

111

Contrasting

Unclassified

Order By: Relevance

“…Average duration for obliteration of these lesions is 5 weeks. 21 Talc sclerotherapy was effective in managing large posttraumatic Morel-Lavallee lesions. This technique has the advantage of avoiding the need for an open procedure.…”

Section: Discussionmentioning

confidence: 99%

“…7,20 Closed degloving injuries can be managed satisfactorily with doxycycline induced obliteration of the cavity with early healing time without recurrences. 21 Regarding the mechanism by which doxycycline induces sclerotherapy, various hypotheses have been proposed like destruction of lining mesothelial cells, inhibition of fibrinolysis and induction of fibroblast growth factors. 22,23 Hence, the resulting fibrosis obliterates the space and prevents recurrence of fluid collection.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Morel-Lavallee lesion in distal thigh: A case report

Kumar¹,

Kumar²

2014

Journal of Clinical Orthopaedics and Trauma

View full text Add to dashboard Cite

Close degloving injury Distal thigh ACL a b s t r a c tIt is a relatively rare condition involving a close degloving injury due to direct trauma with tangential force followed by the separation of the subcutaneous tissue from the underlying fascia. The rupture of small perforating vessels in this area, resulting in the formation of a cavity that filled with blood, lymph and fat foci, the latter being sometimes necrotic. MorelLavallee lesion was originally described in the lateral aspect of the proximal thigh, which is the most common site of this lesion; however other anatomic sites such as periscapular, lumbar and gluteal regions, ankles and knees have been described in the literature. Various methods of treatment has been described, but open debridement can result in a successful functional outcome.Copyright © 2014, Delhi Orthopaedic Association. All rights reserved. IntroductionMorel-Lavallee lesion is a common but rarely described posttraumatic closed soft tissue injury sequel. 1 MLL in distal thigh is a relatively rare condition involving a close degloving injury due to direct trauma with tangential force followed by the separation of the subcutaneous tissue from the underlying fascia. Because of it, the rupture of small perforating vessels in this area, resulting in the formation of a cavity filled with blood, lymph and fat foci, the latter being sometimes necrotic. 2,3 Morel-Lavallee lesion was originally described in the lateral aspect of the proximal thigh, which is the most common site of this lesion; however other anatomic sites such as periscapular, lumbar and gluteal regions, ankles and knees have been described in the literature. 4,5 The case is reported to us with swelling over the anteromedial aspect of distal left thigh with ipsilateral united fracture of medial tibial condyle and partial ACL tear. This type of combination of injuries has not been described previously. Surgical intervention in the form of open debridement was done and resulting in the dramatic improvement. Case reportA 45 years old male presented with swelling over anteromedial aspect of distal left thigh (Fig. 1A þ B). He complained pain left knee during walking and also, weakness left lower limb following trauma. He met with an accident one and half year back, while driving a motorcycle and he was hit by a car from back. He sustained fracture left clavicle, ipsilateral medial tibial condyle and bruises over the anterior aspect of left distal thigh managed conservatively. On follow-up of after one month POP slab was removed and found huge swelling

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Morel-Lavallee lesion in distal thigh: A case report

Kumar¹,

Kumar²

2014

Journal of Clinical Orthopaedics and Trauma

View full text Add to dashboard Cite

show abstract

“…In a recent series of 16 ML lesions treated with doxycycline, all but one responded to a single sitting within 4-8 weeks. The non-responder also regressed on repeating the injection [29]. Timing of sclerotherapy does not seem to influence the outcome.…”

Section: Surgical Managementmentioning

confidence: 92%

“…Different sclerosants used include erythromycin, alcohol, bleomycin, tetracycline, doxycycline, and talc [26][27][28][29]. They act by causing pleural scarring, thereby preventing fluid recurrent accumulation.…”

Section: Surgical Managementmentioning

confidence: 99%

See 1 more Smart Citation

The Morel-Lavallee lesion: a review and a proposed algorithmic approach

et al. 2012

View full text Add to dashboard Cite

Morel-Lavallee lesions (MLL) are rarely diagnosed posttraumatic sequel. They follow closed degloving injuries due to accumulation of blood and debris in the subcutaneous plane. Though they are not uncommon, they are rarely diagnosed which results in delay in their treatment. Diagnosis is through a combination of clinical examination, history, and imaging studies. MRI is the diagnostic modality of choice. Different treatments have been used for their management like compression therapy, sclerosant injection, pulse lavage, and open debridement. These treatments have met with varying success. Treatment protocols vary when managing acute and chronic MLL. The knowledge of such lesions hastens their diagnosis and treatment.

show abstract