DPPH scavenging activity of some Bis-benzimidazole derivatives

Ouaket, Amine; Moughaoui, Fatiha; Laaraibi, Asmae; Hamdouch, Souad; Berrada, M.; Knouzi, N.

doi:10.13171/10.13171/mjc8219041101ao

Mediterr.J.Chem.,

2019

DOI: 10.13171/10.13171/mjc8219041101ao

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DPPH scavenging activity of some Bis-benzimidazole derivatives

Amine Ouaket

Fatiha Moughaoui

Asmae Laaraibi

et al.

Abstract: As part of our research on substituted benzimidazoles, we are interested in the synthesis of new heterocyclic molecules. This new organic molecule is a subclass of quinolines with a wide variety of biological properties. In order to affect the binding of quinoline to our bis-benzimidazole derivatives, we have chosen the "azo" bond as a means of attachment. To achieve our goal, we investigated different parameters for the reactions to determine the conditions to obtain the best results. This article di… Show more

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Cited by 2 publications

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Phytochemical study, polyphenols determination and evaluation of antioxidant activity of Origanum compactum and Satureja calamintha nepeta from the region of Ouazzane (Morocco)

Hayani¹,

Benhlima²,

Bouzoubaa³

et al. 2020

Mediterr.J.Chem.,

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Among natural remedies, aromatic and medicinal plants constitute an essential source that deserves scientific attention. Thus, our study aims to promote the virtues of two aromatic and medicinal plants found in the wild in the region of Ouazzane (Morocco). The phytochemical tests of these species have shown the presence of flavonoids, gallic and catechic tannins, cyanidin, sterols and triterpenes. However, alkaloids, carotenoids, saponosides and reducing compounds were not detected. Then, extraction of total polyphenols from Origanum compactum and Satureja calamintha nepeta was conducted for 48 hours by maceration with a mixture of methanol/water (80/20) used as a solvent. Extractions yielded 35.2% crude extracts for Origanum compactum and 34.4% for Satureja calamintha nepeta. The fractionation of these crude methanol extracts was performed with three organic solvents of increasing polarity (chloroform, ethyl acetate then, n-butanol). Total phenol content of the extracts and fractions was assessed by the method of Folin-Ciocalteu. This revealed that the phenol-rich fractions were the crude extract for Origanum compactum and the butanol fraction for Satureja calamintha nepeta. Finally, the evaluation of the antioxidant power which was carried out using the method of trapping the free radical DPPH• and the reduction of iron by the method of FRAP. The DPPH• test showed a high antioxidant activity of the samples: 53.1 µg/ml of crude extract of Origanum compactum was needed to reduce 50% of DPPH•. The same IC50 was obtained for ascorbic acid (standard antioxidant). For Satureja calamintha nepeta, the IC50 was 67.5 µg/ml. On the other hand, the FRAP test revealed that the methanolic extract of origanum compactum has higher reducing power than that of n-buthanolic extract of satureja calamintha nepeta. Still, it remains relatively low compared to ascorbic acid. The high antioxidant activity of these two species could justify their use in traditional medicine for the treatment of many diseases.

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Phytochemical study, polyphenols determination and evaluation of antioxidant activity of Origanum compactum and Satureja calamintha nepeta from the region of Ouazzane (Morocco)

Hayani¹,

Benhlima²,

Bouzoubaa³

et al. 2020

Mediterr.J.Chem.,

View full text Add to dashboard Cite

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Biological Potency of New Benzimidazole Derived Imine Based Ligand and its Co(III), Ni(II), Cu(II) and Pt(II) Complexes: Synthesis, Structure, Antimicrobial, Antioxidant and BSA Interaction Studies

2020

Biointerface Res Appl Chem

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In this study, we report the synthesis and characterization of transition metal complexes (MC1, MC2, MC3, MC4) where M= Co(III), Ni(II), Cu(II) and Pt(II), respectively, using a new imine-based ligand, 2-{(E)-[(1H-benzimidazol-2-ylmethyl)imino]methyl}-4-bromophenol (HBMB). The molecular structure of the HBMB ligand and its complexes were confirmed by various analytical techniques such as UV-Vis, FT-IR, 1H, 13C-NMR, ESR, TGA/DTA, LC-MS, molar conductance, and magnetic moment measurements. The spectral data of complexes recommended tridentate binding modes of HBMB ligand and suggested an octahedral geometry for MC1 and MC2 complexes while square planar geometry for MC3 and MC4 complexes. Further, the biological activities viz., antimicrobial, antioxidant, and BSA interaction studies were performed using the prepared compounds. The antimicrobial activity results suggested that all the synthesized transition metal complexes showed significant antimicrobial activity against several bacterial and fungal species compared with standard drug and the parent ligand, HBMB. The interaction of metal complexes with BSA (Bovine serum albumin) was performed. The results strongly recommended among the synthesized complexes, platinum complex (MC4) showed marked interaction with the BSA protein. It also indicates that the probable quenching mechanism of BSA fluorescence by complexes is a static quenching procedure, and the spontaneous binding interaction is mainly entropy driven with either van der Waals force or hydrogen binding reaction. The free radical scavenging ability of test samples was assessed using an in vitro assay viz., DPPH.

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DPPH scavenging activity of some Bis-benzimidazole derivatives

Cited by 2 publications

References 15 publications

Phytochemical study, polyphenols determination and evaluation of antioxidant activity of Origanum compactum and Satureja calamintha nepeta from the region of Ouazzane (Morocco)

Phytochemical study, polyphenols determination and evaluation of antioxidant activity of Origanum compactum and Satureja calamintha nepeta from the region of Ouazzane (Morocco)

Biological Potency of New Benzimidazole Derived Imine Based Ligand and its Co(III), Ni(II), Cu(II) and Pt(II) Complexes: Synthesis, Structure, Antimicrobial, Antioxidant and BSA Interaction Studies

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