DPPH Scavenging Assay of Novel 1,3-disubstituted-1H-pyrazol-5-ols and their in silico Studies on Some Proteins Involved in Alzheimers Disease Signaling Cascade

Sarojini, B. K.; Vidyagayatri, Marakkur; Darshanraj, Chenna Govindaraju; Bharath, Basavapattana Rudresh; Manjunatha, H.

doi:10.2174/157018010790596588

Cited by 43 publications

(41 citation statements)

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“…Nitrogen containing five membered heterocyclic compounds could be used as antitumor, antibacterial, antifungal, antiviral, anti-parasitic, anti-tubercular and insecticidal agents [4,5]. They have been studied extensively for useful biological effectiveness such as anti-inflammatory, anti-diabetic, anesthetic and analgesic properties [6,7]. Pyrazole based tridentate ligands often bind metals in a scorpionate fashion and produce significant Corresponding author: Ganna Lyubartseva, Ph.D., assistant professor of chemistry, main research field: coordination chemistry.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Crystal Structure of Bis[1-methoxy-2,2,2-tris-(pyrazol-1-yl-κN2)ethane]-copper(II) Bis-perchlorate

Lyubartseva¹,

Parkin²,

Ngongoni³

et al. 2016

JCCE

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Bis[1-methoxy-2,2,2-tris-(pyrazol-1-yl-κN 2 )ethane]-copper(II) bis-perchlorate (2) was synthesized by reacting of pyrazole based tripodal scorpionate ligand 1-methoxy-2,2,2-tris(pyrazol-1-yl)ethane (1) with copper(II) perchlorate hexahydrate in methanol, acetonitrile and water mixture as solvent. Slow evaporation of the filtered reaction mixture in air produced blue color block crystals suitable for single crystal X-ray diffraction study of the title complex. Compound 2 crystallizes in the monoclinic space group P2 1 /n with unit cell parameters, a = 8.1269(1) Ả, b = 21.8348(2)Ả, c = 9.1522(1) Å, α = γ = 90º, β = 99.7611(4)º. The structure of the compound was characterized by IR Spectroscopy, elemental analysis and single crystal X-ray diffraction analysis.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Crystal Structure of Bis[1-methoxy-2,2,2-tris-(pyrazol-1-yl-κN2)ethane]-copper(II) Bis-perchlorate

Lyubartseva¹,

Parkin²,

Ngongoni³

et al. 2016

JCCE

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“…Various pyrazole derivatves have demonstrated remarkable pharmacological activities including antitumor, antibacterial, antifungal, antiviral, antiparasitic, anti-tubercular and insecticidal properties [4][5][6]. Some of these compounds also exhibit antioxidant, anti-inflammatory and analgesic properties [7][8][9]. The crystal structure of the title compound has recently been determined, but at room temperature only and without any structural discussion [10].…”

Section: Discussionmentioning

confidence: 99%

Redetermination of the structure of 3-methyl-1,5-diphenyl-4,5-dihydro- 1H-pyrazole, C16H16N2

Samshuddin

Narayana

Yathirajan

et al. 2013

Zeitschrift Für Kristallographie - New Crystal Structures

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“…Elemental analysis was carried out by using VARIO EL-III (Elementar Analysensysteme GmBH). The structure of synthesized compounds was characterized by IR, 1 H NMR, 13 C NMR and LCMS analysis. IR spectra were recorded on Shimadzu 8400S FTIR spectrometer using KBr pellets.…”

Section: Lipid Peroxidation Assaymentioning

confidence: 99%

Antibacterial and in vitro antioxidant activities of some 4-amino-1,2,4-triazole-5(4h)-thione derivatives

Manjula¹,

Raj²

2015

J. Fundam and Appl Sci.

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This work represents the synthesis and characterization some new versatile intermediates namely 4-amino-1,2,4-triazole-5(4H)-thione derivatives in a one-step fusion method. The method works to be superior compared to the existing method by Reed and Handel which consists of four steps. The antibacterial activity of compounds is tested against Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, Staphilococcus aureus. The compounds exhibited species specific activity. Among the tested compounds, 1a and 1b exhibited good activity at moderately low concentration (31.25µg/mL) against tested strains of bacteria.DPPH (1,1-diphenyl-2-picryl-hydrazyl), FRAP (ferric reducing antioxidant power) and Lipid peroxidation assays are performed to determine the in vitro antioxidant activities. The compound 1e exhibited good antioxidant activity among the tested compounds.

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DPPH Scavenging Assay of Novel 1,3-disubstituted-1H-pyrazol-5-ols and their in silico Studies on Some Proteins Involved in Alzheimers Disease Signaling Cascade

Cited by 43 publications

References 0 publications

Synthesis, Characterization and Crystal Structure of Bis[1-methoxy-2,2,2-tris-(pyrazol-1-yl-κN2)ethane]-copper(II) Bis-perchlorate

Synthesis, Characterization and Crystal Structure of Bis[1-methoxy-2,2,2-tris-(pyrazol-1-yl-κN2)ethane]-copper(II) Bis-perchlorate

Redetermination of the structure of 3-methyl-1,5-diphenyl-4,5-dihydro- 1H-pyrazole, C16H16N2

Antibacterial and in vitro antioxidant activities of some 4-amino-1,2,4-triazole-5(4h)-thione derivatives

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