DR Antigens in Bullous Pemphigoid

Ahmed, A. Razzaque; Konqui, Alain; Park, Min; Tiwari, Jawahar L.; Terasaki, Paul I.

doi:10.1001/archderm.1984.01650420105026

Cited by 22 publications

(2 citation statements)

References 4 publications

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“…Recent studies have indicated the association of BP with the HLA-DR5 haplotype (Seignalet et al, 1987), which is not incon sistent with our gene mapping data, although some other stud ies have suggested negative correlation between BP and HLA haplotypes (Ahmed et al. 1977(Ahmed et al. , 1984Hashimoto et al, 1979).…”

Section: Resultssupporting

confidence: 79%

Localization of the human gene for 230-kDal bullous pemphigoid autoantigen (BPAG1) to chromosome 6pter→q15

Minoshima

Amagai²,

Kudoh³

et al. 1991

Cytogenet Genome Res

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Chromosome mapping of the human gene encoding the 230-kDal autoantigen of an autoimmune skin disease, bullous pemphigoid, was performed using flow-sorted human chromosomes of cells of normal karyotype and cells carrying a reciprocal translocation t(6;16)(q15;q24). The cDNA of the autoantigen hybridized with intact chromosome 6 and translocation chromosome 6p– (6pter→q15::16q24→qter). The gene (BPA230) was located to the chromosome region 6pter→q15.

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Section: Resultssupporting

confidence: 79%

Localization of the human gene for 230-kDal bullous pemphigoid autoantigen (BPAG1) to chromosome 6pter→q15

Minoshima

Amagai²,

Kudoh³

et al. 1991

Cytogenet Genome Res

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“…Other studies suggest that HLA class I genes may be strictly associated with autoimmune diseases for its role in processing and presenting peptides to T-cells. An association with HLA class I genes has been found in autoimmune diseases such as pemphigus, multiple sclerosis, and type I diabetes, but not in BP [156][157][158][159][160]. Recently, Fang and coworkers studied HLA class I and HLA class II alleles with susceptibility to BP in the northern Chinese Han population.…”

Section: Genetic Susceptibilitymentioning

confidence: 99%

Bullous Pemphigoid: Trigger and Predisposing Factors

et al. 2020

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Bullous pemphigoid (BP) is the most frequent autoimmune subepidermal blistering disease provoked by autoantibodies directed against two hemidesmosomal proteins: BP180 and BP230. Its pathogenesis depends on the interaction between predisposing factors, such as human leukocyte antigen (HLA) genes, comorbidities, aging, and trigger factors. Several trigger factors, such as drugs, thermal or electrical burns, surgical procedures, trauma, ultraviolet irradiation, radiotherapy, chemical preparations, transplants, and infections may induce or exacerbate BP disease. Identification of predisposing and trigger factors can increase the understanding of BP pathogenesis. Furthermore, an accurate anamnesis focused on the recognition of a possible trigger factor can improve prognosis by promptly removing it.

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